Acupuncture and Exercise for Peripheral Neuropathy

(ACE Trial)

This trial explores how acupuncture combined with virtual exercise can help manage chemotherapy-induced peripheral neuropathy (numbness and pain in hands or feet) in individuals with metastatic bladder cancer. Researchers compare two groups: one receiving both acupuncture and virtual exercise, and another receiving only virtual exercise. The trial targets those with advanced bladder cancer undergoing specific chemotherapy treatments who can walk short distances but engage in less than an hour of structured exercise each week. As an unphased trial, it offers a unique opportunity to explore innovative treatments that could improve quality of life.

If you are taking duloxetine, amitriptyline, nortriptyline, gabapentin, or pregabalin, you can continue using them as long as your dosage has been stable for the past three months.

Research has shown that acupuncture is generally safe for people with peripheral neuropathy, including those whose condition results from chemotherapy. Studies have found that acupuncture can improve symptoms without noticeable side effects. Some research even suggests it might be more effective than other treatments, such as medication or sham acupuncture.

Exercise is also widely recommended for many health issues and is usually well-tolerated. It can enhance strength, balance, and overall well-being, with no major safety concerns, especially when guided by a certified trainer.

Researchers are excited about these treatments for peripheral neuropathy because they offer a novel approach by combining acupuncture with virtual exercise. Unlike standard treatments, which often rely on medications to manage symptoms, acupuncture provides a non-pharmacological option that may help improve nerve function and reduce pain. Additionally, the integration of virtual exercise sessions allows for greater accessibility and convenience, making it easier for patients to maintain an active lifestyle, which is crucial for managing neuropathy symptoms. Together, these treatments might enhance patient outcomes by addressing both physical and neurological aspects of the condition in a holistic manner.

Research has shown that acupuncture might help lessen the pain and numbness caused by peripheral neuropathy. Studies have found that acupuncture can improve nerve function and boost blood flow, sometimes more effectively than certain medications. For chemotherapy-induced nerve damage, acupuncture appears very promising, especially when tailored to each individual. In this trial, one group of participants will receive both acupuncture and virtual exercise sessions, while another group will participate in virtual exercise sessions alone. Exercise is known to improve nerve function and ease neuropathy symptoms. Combining acupuncture with exercise might provide more relief than exercise alone.²⁶⁷⁸⁹