Positive Airway Pressure Therapy for Overlap Syndrome

This trial explores the effects of positive airway pressure therapy on individuals with Overlap Syndrome, a combination of sleep apnea and COPD. The researchers aim to determine if this treatment can improve symptoms such as poor sleep and reduced quality of life, which are common in Veterans with this condition. Participants will either receive the therapy or continue with their usual care and education about sleep. Veterans with moderate to severe sleep apnea and COPD, along with a history of smoking, may be suitable candidates for this study. As an unphased trial, this study provides Veterans the chance to contribute to valuable research that could enhance treatment options for Overlap Syndrome.

The trial requires that participants have a stable treatment regimen for COPD, so you should not stop your current COPD medications. However, if you are taking medicines that cause or alter sleepiness, like sedative hypnotics or stimulants, you may need to stop those as they are excluded from the trial.

Research has shown that therapies like CPAP (Continuous Positive Airway Pressure) and BiPAP (Bilevel Positive Airway Pressure) are generally safe for individuals with obstructive sleep apnea and COPD. Studies indicate that these therapies can improve breathing and reduce symptoms. Most patients tolerate the treatment well, experiencing only minor side effects.

Researchers are excited about Positive Airway Pressure (PAP) therapy for overlap syndrome because it offers a targeted approach to managing this condition. Overlap syndrome, which combines features of both obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD), is traditionally managed with separate treatments for each condition. PAP therapy stands out because it directly addresses the breathing issues associated with both OSA and COPD simultaneously, potentially improving outcomes for patients by enhancing sleep quality and respiratory function. This integrated approach could offer a more cohesive and efficient treatment option compared to managing each condition separately.

Studies have shown that positive airway pressure (PAP) therapy can benefit individuals with overlap syndrome, a condition involving both obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD). In this trial, some participants will receive PAP therapy, which research indicates often improves sleep and reduces symptom severity. People using PAP therapy have reported feeling less sleepy during the day and experiencing fewer health issues related to these conditions. One study found that PAP therapy can lower blood pressure and reduce car accidents caused by sleepiness. Overall, PAP therapy offers a promising approach to managing the challenging symptoms of overlap syndrome. Meanwhile, other participants in this trial will receive conservative care, including education about sleep apnea and sleep hygiene.³⁶⁷⁸⁹