Inulin for Irritable Bowel Syndrome

This trial examines how inulin, a type of fiber, affects gut bacteria and digestive processes in individuals with irritable bowel syndrome (IBS). Researchers aim to determine if changes in gut bacteria and the production of certain acids in the gut are linked to IBS symptoms. Participants will include individuals with IBS, either diarrhea- or constipation-predominant, and healthy individuals without gut issues. Those who have IBS symptoms and meet the Rome IV criteria (guidelines for diagnosing IBS) or are healthy with no digestive problems may be suitable candidates. As an unphased trial, this study seeks to explore new insights into IBS, offering participants the opportunity to contribute to groundbreaking research.

You may need to stop taking certain medications that affect gastrointestinal function, like opioids, inflammatory drugs, or certain antidepressants, within 2 days before the study if you have IBS. However, stable low doses of antidepressants taken for more than a month may be allowed. Rescue medication for constipation is permitted if needed.

Studies have shown that inulin, a type of dietary fiber, is generally easy for people to tolerate. Inulin supports good bacteria, improving gut health. Some individuals might experience mild side effects like bloating or gas, but these usually subside and often occur if introduced too quickly. Research indicates that daily fiber supplements like inulin are safe. However, one study found that a different type of fiber used in another trial caused more side effects and worsened symptoms for some individuals with IBS. Overall, inulin is considered safe for most people, but starting slowly and observing the body's response is advisable.¹²³⁴⁵

Most treatments for irritable bowel syndrome (IBS) focus on managing symptoms with medications like antispasmodics, laxatives, or anti-diarrheal drugs. However, inulin is unique because it is a natural dietary fiber that may help balance gut bacteria, which is thought to play a role in IBS symptoms. Researchers are excited about inulin because it offers a potentially more natural approach by promoting healthy digestion and gut health, rather than simply masking symptoms. Its ability to support a healthier gut environment could make it a promising alternative or complement to existing therapies.

Research has shown that inulin, a type of soluble fiber, can help alleviate irritable bowel syndrome (IBS) symptoms. Studies have found that inulin can increase weekly bowel movements and improve stool consistency, benefiting those with IBS. One study found that inulin intake made bowel movements more regular and consistent, as measured by the Bristol Stool Form Scale. However, some research suggests that the improvements might not differ significantly from a placebo, indicating that results can vary among individuals. Overall, many guidelines recommend soluble fiber like inulin as a good first step in managing IBS symptoms.