Cyanoacrylate Skin Adhesive for Surgical Site Infection in Skin Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether using a skin adhesive called cyanoacrylate can reduce infections after skin cancer surgery. Participants will have their surgical site closed either with or without this adhesive to determine its effectiveness in preventing infections within 30 days. The study will also assess scar quality, satisfaction with treatment, and ease of wound care. It is suitable for those undergoing Mohs micrographic surgery or wide local excision for skin cancer, where the surgical site can be closed with a standard stitch. As an unphased trial, this study offers participants the chance to contribute to innovative research that could enhance post-surgical outcomes.
Do I need to stop taking my current medications for this trial?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are currently using systemic antibiotics for an unrelated condition at the time of surgery.
What prior data suggests that cyanoacrylate skin adhesive is safe for use in surgical site infection prevention?
Research has shown that cyanoacrylate skin glue is generally safe for closing wounds. Studies have found that it seals cuts effectively, offering a quick and mostly painless method for wound repair. Most people tolerate the glue well without major issues.
However, some potential risks exist. Inhaling cyanoacrylate or excessive skin exposure can be harmful, though these situations are rare and typically occur in industrial settings, not in standard medical use. Overall, the glue is considered safe in medical settings, with very few negative effects reported.12345Why are researchers excited about this trial?
Researchers are excited about using cyanoacrylate skin adhesive to prevent surgical site infections in skin cancer surgeries because it offers a unique way to protect wounds. Unlike traditional methods that rely solely on sutures, this adhesive forms a protective barrier over the incision, potentially reducing infection risk. Additionally, it may enhance healing by sealing the skin more effectively and minimizing exposure to bacteria. This approach could lead to quicker recovery times and less scarring, making it an appealing option compared to standard suture-only techniques.
What evidence suggests that this trial's treatments could be effective for surgical site infection in skin cancer?
Research has shown that cyanoacrylate skin adhesive can reduce infections after surgery. Studies have found that this glue has germ-fighting properties, preventing infections. It also closes wounds faster than regular stitches, potentially improving healing and reducing stress. Additionally, it often causes less pain and looks better than traditional stitches. In this trial, some participants will receive sutures with cyanoacrylate skin adhesive, while others will receive sutures without it. These findings suggest that cyanoacrylate skin adhesive can improve surgical wound care.678910
Who Is on the Research Team?
Chandler Rundle, MD
Principal Investigator
University of Minnesota
Are You a Good Fit for This Trial?
This trial is for adults having Mohs surgery or wide local excision to remove skin cancer, where the wound can be closed in a straight line. Participants must be able to have stitches and follow-up care.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Surgery and Treatment
Participants undergo Mohs micrographic surgery or wide local excision followed by randomized closure with or without cyanoacrylate skin adhesive
Follow-up
Participants are monitored for surgical site infection, wound healing, and other outcomes
What Are the Treatments Tested in This Trial?
Interventions
- Cyanoacrylate Skin Adhesive
Trial Overview
The study compares using surgical glue (cyanoacrylate skin adhesive) plus stitches versus stitches alone after skin cancer removal. Different types of running sutures are used, and patients are randomly assigned to groups.
How Is the Trial Designed?
6
Treatment groups
Experimental Treatment
Active Control
Participants in the absorbable suture stratum will receive standardized running epidermal closure using Vicryl Rapide sutures followed by cyanoacrylate skin adhesive.
Participants in the non-absorbable suture stratum will receive standardized running epidermal closure using Prolene sutures followed by cyanoacrylate skin adhesive.
Participants in the absorbable suture stratum will receive standardized running epidermal closure using fast gut sutures followed by cyanoacrylate skin adhesive.
Participants in the absorbable suture stratum will receive standardized running epidermal closure using fast gut sutures without cyanoacrylate skin adhesive.
Participants in the absorbable suture stratum will receive standardized running epidermal closure using Vicryl Rapide sutures without cyanoacrylate skin adhesive.
Participants in the non-absorbable suture stratum will receive standardized running epidermal closure using Prolene sutures without cyanoacrylate skin adhesive.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Minnesota
Lead Sponsor
Citations
Efficacy of cyanoacrylate glue in operative wound closure
Conclusions:Use of cyanoacrylate glue was found to be more effective and conventional suturing.
2.
ctv.veeva.com
ctv.veeva.com/study/post-operative-skin-approximation-with-cyanoacrylate-based-wound-closure-adhesivesPost Operative Skin Approximation With Cyanoacrylate Based ...
Because these products do not require stitching deep into the skin, they can reduce the time it takes to close a wound and may reduce stress or ...
3.
woundsinternational.com
woundsinternational.com/journal-articles/cost-effectiveness-wound-treatment-cyanoacrylate-topical-adhesive-primary-health-care-units-region-portugal/Cost-effectiveness of wound treatment with cyanoacrylate ...
The study focuses on the cost-effectiveness analysis of wound treatment with cyanoacrylate topical adhesive, skin glue.
Cyanoacrylates for Skin Closure
Previous clinical trials showed that CA glue is safe, wound closure took significantly less time than suture repair, and exhibited antimicrobial properties; ...
5.
researchgate.net
researchgate.net/publication/331001982_A_comparative_study_between_conventional_skin_sutures_staples_adhesive_skin_glue_for_surgical_skin_closureA comparative study between conventional skin sutures ...
Skin glue gives the best results in terms of less post-operative pain, wound asepsis, better cosmesis and cost-effectiveness.
Adhesive
cyanoacrylates and urethanes. Exposure can occur by direct contact or inhalation of fumes and is potentially life-threatening.
A randomized trial comparing octylcyanoacrylate tissue ...
Conclusions: Octylcyanoacrylate tissue adhesive effectively closes selected lacerations. This relatively painless and fast method of wound repair can replace ...
Adhesive | Definition, Types, Uses, Materials, & Facts
Cyanoacrylates bond quickly to plastic and rubber but have limited temperature and moisture resistance. is often the site of environmental attack, leading to ...
ADHESIVE Definition & Meaning
The meaning of ADHESIVE is tending to remain in association or memory. characterized by the formation of new fibrous tissue resulting from an ...
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