THRIVE for Suicide Prevention
(THRIVE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The trial aims to test the effectiveness of a new treatment called THRIVE in reducing suicide risk for adults treated at a Crisis Stabilization Center (CSC). THRIVE includes a 60-minute group therapy session focused on recovery and meaningful living, followed by up to six supportive phone calls after leaving the center. The study will compare standard care at CSCs to standard care plus THRIVE to determine if the new treatment reduces future suicide-related events. Adults admitted to a CSC due to suicidal thoughts and who can communicate in English may be eligible to participate. As an unphased trial, this study provides a unique opportunity to contribute to research that could enhance care for those at risk of suicide.
What prior data suggests that the THRIVE intervention is safe for adults receiving care for suicide risk?
Research has shown that treatments focusing on social support and hope can significantly reduce the risk of suicidal thoughts and attempts. For instance, individuals with strong social support are about 40% less likely to experience these thoughts and attempts. Additionally, increased hope correlates with fewer suicidal thoughts. These findings suggest that programs like THRIVE, which emphasize connection, meaningful living, and recovery, can be safe and beneficial for those at risk. Although no specific negative effects of THRIVE have been reported, its components are based on proven protective factors that are generally well-tolerated.12345
Why are researchers excited about this trial?
Researchers are excited about the THRIVE approach for suicide prevention because it introduces a unique blend of narrative therapy and peer-led recovery coaching, which is not common in standard care. Unlike traditional treatments that focus mainly on medication management and basic crisis interventions, THRIVE emphasizes creating a safe space for individuals to share their experiences and develop a Meaningful Living Plan. This personalized and proactive approach aims to empower individuals by integrating them into their community and supporting them in their recovery journey, offering a promising new direction for suicide prevention.
What evidence suggests that THRIVE could be an effective treatment for suicide prevention?
Research has shown that special programs for preventing suicide can improve mental health and reduce suicidal actions. In this trial, participants may receive the THRIVE program, which focuses on recovery and finding meaning in life. THRIVE includes group therapy sessions and follow-up support for people in crisis. Although specific data on THRIVE's effectiveness is limited, it is based on proven methods that lower the risk of suicide. Early results from similar programs have shown positive signs of reducing suicide attempts and improving overall well-being.26789
Who Is on the Research Team?
Jennifer D Lockman, PhD
Principal Investigator
University of Alabama at Birmingham
Are You a Good Fit for This Trial?
This trial is for adults (18 or older) admitted to a Crisis Stabilization Center due to suicidal thoughts or crisis, who can communicate in English and are able to provide emergency contact information. People with severe psychiatric instability that prevents participation, or those under 18, cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive the THRIVE intervention, including a 60-minute group psychotherapy session during the CSC stay and up to six peer-led recovery coaching calls post-discharge
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments at 3, 6, and 12 months post-discharge
What Are the Treatments Tested in This Trial?
Interventions
- Toward Hope, Recovery, Interpersonal Growth, Values, and Engagement (THRIVE)
Trial Overview
The study compares usual care at Crisis Stabilization Centers with and without an added program called THRIVE. THRIVE includes a one-hour group therapy session during the stay plus up to six follow-up calls from peer coaches after discharge. Participants are randomly assigned to each group.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Behavioral: THRIVE Toward Hope, Recovery, Interpersonal Growth, Values and Engagement (THRIVE), is a brief, suicide-specific, narrative, recovery-focused, 60 minute group psychotherapy intervention followed by up to 6 peer-led recovery coaching phone calls. THRIVE includes five components: 1) Creating a Safe Space for Disclosure; 2) Psychoeducation on Suicide Recovery; 3) Sharing the Suicide Narrative; 4) Completing the Meaningful Living Plan; 5) Taking Action on the Meaningful Living Plan in the Community. Behavioral: Usual Care Care as Usual in Crisis Stabilization Centers includes medication management, the safety planning Intervention, group psychoeducation, individual counseling, discharge planning, and community referral linkages
Care as Usual in the Crisis Stabilization Centers includes medication management, the safety planning Intervention, individual counseling, group psychoeducation, discharge planning, and community referral linkages.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alabama at Birmingham
Lead Sponsor
National Institute of Mental Health (NIMH)
Collaborator
Citations
Bridge the Gap for Suicide Prevention (Bridge the Gap Trial)
One study found that specialized suicide prevention programs can greatly improve mental health and reduce suicidal behaviors. These programs also help boost ...
2.
rivcospc.org
rivcospc.org/sites/default/files/DATA/pdfs/Year%20One%20Accomplishments%20Infographic%20NEW%20LOGO%20PDF%20.pdfBuilding Hope and Resiliency - Putting the ...
Total suicide deaths for 2020 have shown decreases and downward trends. Preliminary 2020 data on suicide attempts is not expected to show dramatic increases.
3.
scispace.com
scispace.com/pdf/user-engagement-and-usability-of-suicide-prevention-apps-10pi39cs2q.pdfUser Engagement and Usability of Suicide Prevention Apps
Results: Of the 66 apps identified, 42 (64%) were specifically designed for people with suicidal ideation, and 59 (89%) had at least one best practice feature ...
4.
aaas.org
aaas.org/sites/default/files/2026-01/AAASEPI_CSGMW_EarlyIntervention_YouthMentalHealth01132025.pdfEvidence-Based Pathways for Youth Mental Health and ...
We serve as the lead entity for suicide prevention, intervention supports, and postvention efforts in Colorado, collaborating with communities.
5.
researchgate.net
researchgate.net/publication/390143626_The_Hope_Institute_Approach_to_Suicidal_RiskThe Hope Institute Approach to Suicidal Risk
Over 16 million Americans struggle with serious thoughts of suicide; deaths by suicide have increased significantly over the past 30 years ...
User Engagement and Usability of Suicide Prevention Apps
This study identified many usable and engaging apps in app stores designed for suicide prevention. However, there are only limited apps for ...
7.
theconversation.com
theconversation.com/suicide-prevention-protective-factors-can-build-hope-and-mitigate-risks-198474Suicide prevention: Protective factors can build hope and ...
Individuals who perceived they had strong social support had an approximately 40 per cent reduced risk of suicidal ideation and attempts.
8.
digital.lib.washington.edu
digital.lib.washington.edu/server/api/core/bitstreams/cb876293-945d-44fc-bded-ebfbdb4b9819/content1 Crisis Outreach, Treatment Engagement, and Outcomes ...
Participants reached by care navigators showed steeper and sustained reductions in SI, depression, and anxiety symptoms over 6 months. • Findings support ...
9.
omicsonline.org
omicsonline.org/open-access-pdfs/strengthening-the-framework-of-suicide-prevention-building-hope-and-resilience-in-a-changing-world.pdfStrengthening the Framework of Suicide Prevention
By recognizing the widespread impact of trauma and prioritizing empathy, safety, and empowerment, TIC offers a humane and effective pathway toward recovery.
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