THRIVE for Suicide Prevention

(THRIVE Trial)

Not yet recruiting at 2 trial locations
JD
FL
Overseen ByFallan Lloyd, B.S.
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Alabama at Birmingham
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The trial aims to test the effectiveness of a new treatment called THRIVE in reducing suicide risk for adults treated at a Crisis Stabilization Center (CSC). THRIVE includes a 60-minute group therapy session focused on recovery and meaningful living, followed by up to six supportive phone calls after leaving the center. The study will compare standard care at CSCs to standard care plus THRIVE to determine if the new treatment reduces future suicide-related events. Adults admitted to a CSC due to suicidal thoughts and who can communicate in English may be eligible to participate. As an unphased trial, this study provides a unique opportunity to contribute to research that could enhance care for those at risk of suicide.

What prior data suggests that the THRIVE intervention is safe for adults receiving care for suicide risk?

Research has shown that treatments focusing on social support and hope can significantly reduce the risk of suicidal thoughts and attempts. For instance, individuals with strong social support are about 40% less likely to experience these thoughts and attempts. Additionally, increased hope correlates with fewer suicidal thoughts. These findings suggest that programs like THRIVE, which emphasize connection, meaningful living, and recovery, can be safe and beneficial for those at risk. Although no specific negative effects of THRIVE have been reported, its components are based on proven protective factors that are generally well-tolerated.12345

Why are researchers excited about this trial?

Researchers are excited about the THRIVE approach for suicide prevention because it introduces a unique blend of narrative therapy and peer-led recovery coaching, which is not common in standard care. Unlike traditional treatments that focus mainly on medication management and basic crisis interventions, THRIVE emphasizes creating a safe space for individuals to share their experiences and develop a Meaningful Living Plan. This personalized and proactive approach aims to empower individuals by integrating them into their community and supporting them in their recovery journey, offering a promising new direction for suicide prevention.

What evidence suggests that THRIVE could be an effective treatment for suicide prevention?

Research has shown that special programs for preventing suicide can improve mental health and reduce suicidal actions. In this trial, participants may receive the THRIVE program, which focuses on recovery and finding meaning in life. THRIVE includes group therapy sessions and follow-up support for people in crisis. Although specific data on THRIVE's effectiveness is limited, it is based on proven methods that lower the risk of suicide. Early results from similar programs have shown positive signs of reducing suicide attempts and improving overall well-being.26789

Who Is on the Research Team?

JD

Jennifer D Lockman, PhD

Principal Investigator

University of Alabama at Birmingham

Are You a Good Fit for This Trial?

This trial is for adults (18 or older) admitted to a Crisis Stabilization Center due to suicidal thoughts or crisis, who can communicate in English and are able to provide emergency contact information. People with severe psychiatric instability that prevents participation, or those under 18, cannot join.

Inclusion Criteria

Admission to CSC with suicidal crisis, defined by active suicide ideation ascertained by the Columbia Suicide-Severity Rating scale (C-SSRS)
I can give contact details for someone in case of emergency.

Exclusion Criteria

I do not have severe psychiatric symptoms that prevent me from joining therapy.
I am under 18 years old.
I am not able to communicate in English with the research team.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive the THRIVE intervention, including a 60-minute group psychotherapy session during the CSC stay and up to six peer-led recovery coaching calls post-discharge

6 weeks
1 in-person visit, up to 6 phone calls

Follow-up

Participants are monitored for safety and effectiveness after treatment, with assessments at 3, 6, and 12 months post-discharge

12 months
Assessments at 3, 6, and 12 months

What Are the Treatments Tested in This Trial?

Interventions

  • Toward Hope, Recovery, Interpersonal Growth, Values, and Engagement (THRIVE)

Trial Overview

The study compares usual care at Crisis Stabilization Centers with and without an added program called THRIVE. THRIVE includes a one-hour group therapy session during the stay plus up to six follow-up calls from peer coaches after discharge. Participants are randomly assigned to each group.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Care as Usual + THRIVEExperimental Treatment2 Interventions
Group II: Care as UsualActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Alabama at Birmingham

Lead Sponsor

Trials
1,677
Recruited
2,458,000+

National Institute of Mental Health (NIMH)

Collaborator

Trials
3,007
Recruited
2,852,000+

Citations

Bridge the Gap for Suicide Prevention (Bridge the Gap Trial)

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Total suicide deaths for 2020 have shown decreases and downward trends. Preliminary 2020 data on suicide attempts is not expected to show dramatic increases.

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Evidence-Based Pathways for Youth Mental Health and ...

We serve as the lead entity for suicide prevention, intervention supports, and postvention efforts in Colorado, collaborating with communities.

The Hope Institute Approach to Suicidal Risk

Over 16 million Americans struggle with serious thoughts of suicide; deaths by suicide have increased significantly over the past 30 years ...

6.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/34259163/

User Engagement and Usability of Suicide Prevention Apps

This study identified many usable and engaging apps in app stores designed for suicide prevention. However, there are only limited apps for ...

Suicide prevention: Protective factors can build hope and ...

Individuals who perceived they had strong social support had an approximately 40 per cent reduced risk of suicidal ideation and attempts.

1 Crisis Outreach, Treatment Engagement, and Outcomes ...

Participants reached by care navigators showed steeper and sustained reductions in SI, depression, and anxiety symptoms over 6 months. • Findings support ...

Strengthening the Framework of Suicide Prevention

By recognizing the widespread impact of trauma and prioritizing empathy, safety, and empowerment, TIC offers a humane and effective pathway toward recovery.