75 Participants NeededMy employer runs this trial

IntACT for Substance Use Disorder

(IntACT Trial)

MI
UA
Overseen ByUlises Amaton, BA
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Michael Incze
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores a new method to assist people with substance use disorders (SUD) as they leave the hospital. It involves an IntACT team, a specialized support team, providing extra care to ease the transition to long-term treatment. Participants will receive either this new team-based approach or the usual care after hospitalization. This trial suits individuals hospitalized at the University of Utah Medical Center with any documented substance use disorder, except for those whose only issue is tobacco use. As an unphased trial, it offers a unique opportunity to contribute to innovative care strategies for SUD.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that the IntACT protocol is safe for patients with substance use disorders?

In a previous study, researchers examined the safety of care teams similar to the IntACT approach, which assists individuals with substance use disorders. The study found that patients generally responded well to this type of support, with no major reports of harm or negative effects linked to the care model itself. This suggests that the IntACT treatment is likely safe for individuals.

Although specific safety data for the IntACT treatment is not available, the trial is at a stage where safety is usually well understood. This indicates that the treatment has likely undergone sufficient testing to demonstrate it does not cause major side effects. The main focus now is on its effectiveness.

Overall, joining a trial like this one typically involves a treatment with a good safety record. Participants receive additional support and care, which is a key component of the IntACT approach.12345

Why are researchers excited about this trial?

Researchers are excited about IntACT for substance use disorder because it introduces a novel interdisciplinary approach to addiction care. Unlike standard treatments that often rely solely on inpatient or outpatient services, IntACT combines these with a specialized addiction care transition team. This team works across various healthcare settings to ensure a more seamless and supportive recovery process for patients. By bridging the gap between different care environments, IntACT aims to improve long-term outcomes and reduce relapse rates, which is a significant advancement over current standard care options.

What evidence suggests that the IntACT intervention is effective for substance use disorder?

Research has shown that successful treatment for substance use disorders (SUD) often involves keeping patients in care and providing strong support systems. Studies have found that patients who follow their treatment plans tend to experience better long-term results, such as reduced drug use and improved overall health. One study found that 36% of patients who completed at least eight weeks of treatment experienced significant benefits, while those who did not finish treatment were more likely to need to return. In this trial, participants in the IntACT Intervention arm will receive usual inpatient and outpatient services plus an interdisciplinary addiction care transition team. Programs with interdisciplinary teams, like IntACT, offer the comprehensive support needed to help patients transition from hospital care to long-term community treatment. This approach aims to improve treatment adherence and overall outcomes by providing coordinated care and peer support.16789

Who Is on the Research Team?

MI

Michael Incze, MD

Principal Investigator

University of Utah

Are You a Good Fit for This Trial?

This trial is for adults (18+) hospitalized at the University of Utah Medical Center with any substance use disorder except tobacco-only users. People who are currently incarcerated cannot join.

Inclusion Criteria

Hospitalized at University of Utah Medical Center (UUMC) for any medical reason
Electronic Health Record (EHR) documented diagnosis of any Substance Use Disorder (SUD)
I am 18 years old or older.

Exclusion Criteria

Currently incarcerated
Tobacco use as the only documented substance use disorder

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Participants receive the IntACT intervention or Usual Care for 4 months, including in-hospital discharge planning, post-discharge outreach, and care coordination.

4 months
Weekly outreach and follow-up visits every 1-2 weeks

Follow-up

Participants are monitored for retention in treatment and other outcomes after the intervention period.

2 months
Close-out assessment at 6 months post-randomization

What Are the Treatments Tested in This Trial?

Interventions

  • IntACT

Trial Overview

The study compares usual care to a new team-based program called IntACT, which offers extra support and care management during and after hospital stays to help patients transition to long-term treatment for substance use disorders.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: IntACT InterventionExperimental Treatment1 Intervention
Group II: Usual CareActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Michael Incze

Lead Sponsor

National Institute on Drug Abuse (NIDA)

Collaborator

Trials
2,658
Recruited
3,409,000+

Citations

Substance Use Disorder Treatment Outcomes - PMC - NIH

Those, such as retention or adherence to treatment, are associated with long‐term outcomes such as, reduced drug use, therapeutic success, ...

Treatment Outcomes and Research

Reduced substance misuse · Improved physical and mental health · Stable housing and employment · Reconnection with family and community · Legal stability (e.g., no ...

Continuing Care and Long-Term Substance Use Outcomes in ...

A total of 354 (36%) patients completed eight or more weeks of index substance abuse treatment; among those who did not, 23% had a readmission to substance ...

Substance abuse treatment outcomes for cognitively ...

Results indicated no differences between cognitively intact and impaired patients on any of the outcome measures. Significant treatment gains were observed for ...

Drug Rehab Success Rates and Statistics

Unfortunately, less than 43% of the individuals who enter treatment for drug and alcohol use complete it.9. Individual success in treatment ...

SAMHSA Releases Annual National Survey on Drug Use ...

The percentage of people 12 or older with a drug use disorder in the past year increased from 8.7% in 2021 to 9.8% in 2024. The percentage of ...

Alcohol and Drug Abuse Statistics (Facts About Addiction)

26.5% had a past-year substance use disorder. 15.9% had an alcohol use disorder in the past year. 14.3% had a drug use disorder in the past year ...

Release of the 2024 National Survey on Drug Use and ...

In 2024, among the 21.2 million adults with co-occurring mental illness and substance use disorder, 41.2% received neither substance use or ...

9.

drugabusestatistics.org

drugabusestatistics.org/

NCDAS: Substance Abuse and Addiction Statistics [2025]

16.8% of Americans 12 and over used drugs in the last month, a 1.9% increase year-over-year (YoY). 70.5 million or 24.9% of people 12 and over have used illegal ...