DEST2nation Model for HIV/AIDS
(DEST2nation 3 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
One out of six people with HIV (PWH) in the U.S. are incarcerated annually; two-thirds of individuals who are incarcerated meet criteria for substance use disorder (SUD) and many more in carceral settings have risk factors for HIV. Ending the U.S. HIV epidemic hinges on linking and engaging people with criminal legal system involvement (PCLSI) with HIV or related risk factors, especially those with SUDs, to optimize antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) uptake and adherence.
In this study, the investigator team will pursue Aim 1 (R33): Test the DEST2nation model in a multisite randomized control trial; and Aim 2 (R33): Estimate the cost of implementing and sustaining a decentralized, status neutral model and estimate its economic value from healthcare sector, state-policymaker, and societal perspectives.
Who Is on the Research Team?
Matthew Akiyama, MD, MSc
Principal Investigator
Albert Einstein College of Medicine Montefiore Medical Center
Are You a Good Fit for This Trial?
This trial is for people who have been involved with the criminal justice system and are living with HIV or at risk for HIV, including those with substance use disorders. Participants may also have conditions like Burkitt Lymphoma or other substance abuse issues.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- DEST2nation model
Trial Overview
The study compares the usual referral process to a new approach called the DEST2nation model, which aims to better connect recently incarcerated individuals to HIV care and prevention services. Participants are randomly assigned to one of these two groups.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
A Community Health Advocate (CHA) will meet with participants once a month for six months, with two phone check-ins per month, to provide: rapid HIV testing every 3 months for participants who are HIV-negative or of unknown status; HIV and substance use education; substance use assessment and counseling; help finding and scheduling HIV, PrEP, substance use, and mental health care; accompaniment to medical appointments; connection to community-based organization (CBO) resources; and supportive counseling to discuss health and life concerns. Participants also receive the standard-of-care referral to community care.
Participants receive a referral to a community clinic for HIV-related care, with follow-up contacts at 1.5 and 3 months after enrollment to confirm whether an appointment was made and kept. Participants also have access to the CBO's usual case management services.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Montefiore Medical Center
Lead Sponsor
The Fortune Society
Collaborator
Philadelphia Fight
Collaborator
Cornell University/Weill Cornell Medical Center
Collaborator
National Institute on Drug Abuse (NIDA)
Collaborator
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