Peer-Delivered Behavioral Activation for Depression

JF
Overseen ByJulia Felton, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Wayne State University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to evaluate the effectiveness of a program called Peer Activate in helping people with depression. Peer Activate consists of sessions led by peer recovery specialists who have overcome their own mental health or substance use challenges. The program encourages individuals to engage in positive activities to reduce depression and substance use symptoms. Potential participants include those with significant depression symptoms who receive care in a community setting that provides both physical and mental health services. As an unphased trial, this study provides a unique opportunity to explore innovative support methods for depression.

Do I need to stop my current medications to join the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that Behavioral Activation (BA) is generally safe and well-tolerated. Many studies indicate that BA, which improves mood by encouraging participation in positive activities, effectively reduces symptoms of depression. This is particularly true for individuals with depression and substance use issues, the focus of this trial.

These studies report no major side effects or safety concerns. In fact, BA has been compared to other treatments like cognitive-behavioral therapy (CBT) and found to be just as effective, with the added benefit of saving time.

In summary, evidence suggests that BA is a safe option for treating depression, with no major safety issues reported in past research.12345

Why are researchers excited about this trial?

Researchers are excited about Peer Activate because it offers a fresh approach to treating depression, especially for those with substance use disorders (SUD). Unlike typical treatments that might rely on medication or therapist-led interventions, Peer Activate is delivered by peer recovery specialists who have personal experience with recovery. This method focuses on Behavioral Activation (BA), which encourages individuals to engage in positive, rewarding activities, enhancing their overall mood and reducing depressive symptoms. What makes it particularly promising is its dual focus on alleviating depression and improving substance use outcomes, making it a potentially valuable tool for those struggling with both challenges.

What evidence suggests that Peer Activate could be an effective treatment for depression?

Research has shown that Peer Activate, one of the treatments in this trial, helps reduce depression and improve substance use habits in low-income individuals with substance use disorder (SUD). Studies found that participants significantly reduced their substance use, with 97% adhering to their methadone treatment after the program. The program encourages positive actions that boost well-being, easing depression. Peer recovery specialists, who have personal recovery experience, deliver the program, making it relatable and easy to understand. This approach works well, especially in community settings that combine physical and mental healthcare. Another treatment arm in this trial involves Enhanced Treatment as Usual, which includes peer-delivered non-directive support and facilitated linkages to care.678910

Are You a Good Fit for This Trial?

This trial is for low-income individuals struggling with substance use disorder or depression, including major depressive disorder. Participants should be receiving services from a community-based treatment setting that offers integrated physical and behavioral healthcare.

Inclusion Criteria

I am 18 years old or older.
I have symptoms of depression with a PHQ-9 score of 8 or higher.

Exclusion Criteria

Active, under treated psychotic symptoms or mania that would interfere with participation in study procedures
I cannot understand or speak English well enough to give informed consent.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive the Peer Activate intervention, which includes 6 weekly sessions with up to 6 additional booster sessions

6-12 weeks

Follow-up

Participants are monitored for changes in depression and substance use outcomes at post-intervention, 6- and 12-month follow-up

12 months

What Are the Treatments Tested in This Trial?

Interventions

  • Peer Activate
  • Peer-delivered non-specific services
Trial Overview The study tests the effectiveness of Behavioral Activation, an evidence-based mental health intervention delivered by peer recovery specialists—people who have overcome their own mental health and substance use issues.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Behavioral ActivationExperimental Treatment1 Intervention
Group II: Enhanced Treatment as UsualActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Wayne State University

Lead Sponsor

Trials
318
Recruited
111,000+

University of Maryland, College Park

Collaborator

Trials
163
Recruited
46,800+

Citations

Peer-Delivered Behavioral Activation in a CCBHCBA has been found to be effective in improving substance use outcomes and decreasing depressive symptoms among low-income individuals with SUD.
Hybrid Effectiveness-Implementation Trial to Evaluate a ...This study aims to test how a peer-delivered behavioral activation approach can simultaneously address both substance use and depression outcomes.
Peer-Delivered Behavioral Activation Intervention to Improve ...We will establish the preliminary feasibility, acceptability and fidelity of Peer Activate in an open-label trial (n=30) and pilot Phase 2 study procedures, ...
“HEAL together”: a randomized, hybrid type 1 effectiveness ...This trial will provide insight as to whether a PRS-delivered intervention may be effective and feasible for improving methadone treatment retention.
Peer recovery specialist-delivered, behavioral activation ...Among Peer Activate participants, urine-verified methadone adherence reached 97% at post-intervention, and there was a significant reduction in substance use ...
Efficacy and safety of behavioural activation on depression ...Six studies rated as low risk of bias. For short-term follow-ups (up to 6 months), meta-analysis showed behavioural activation had little effect on depression ...
A Behavioral Activation Digital Intervention Incorporating ...BA is an evidence-based psychological treatment for adolescent depression that has been shown to be effective in both clinical and subthreshold ...
The efficacy of behavioural activation treatment for co ...Empirical evidence suggests that behavioural activation therapy is just as effective as CBT [37, 38], and is more time efficient and less ...
Behavioral activation interventions for well-being: A meta- ...The results revealed that PPIs enhance well-being and ameliorate depressive symptoms, and that these effects are enhanced for individuals with depression.
Study Details | NCT06786247 | Evaluation of an ...The goal of this clinical trial is to learn if a digital health intervention, called "ActivaTeen," improves depression treatment for teenagers with ...
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