Sleep Deprivation and Alcohol Intoxication for Neurobehavioral Changes
(NeuroSTAR Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study aims to investigate the impairing effects of known central nervous system (CNS) stressors in a controlled environment in order to predict and mitigate analogous risks in spaceflight. Up to 56 healthy individuals aged 25-60 will spend approx. 110 hours in a laboratory, where they will be exposed to 27 hours of sleep deprivation and will consume alcohol to reach a BAC of 0.08 on a separate day. They will perform cognitive and sensorimotor tasks and undergo MRIs and blood draws.
Who Is on the Research Team?
Mathias Basner, MD, PhD, MScEpi
Principal Investigator
University of Pennsylvania
Are You a Good Fit for This Trial?
This trial is for healthy adults aged 25-60 who have a regular sleep schedule, get 6-8.5 hours of sleep nightly, can stand and lift their arms easily, have a BMI between 18.5 and 35, are free from major health or psychiatric issues, and can read and write English.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Trial Overview
Researchers are studying how lack of sleep (27 hours awake) and moderate alcohol use (BAC up to 0.08), compared to no intervention (control), affect thinking skills and movement in a lab setting over about five days.
How Is the Trial Designed?
6
Treatment groups
Experimental Treatment
Group F will experience the interventions in the following order, following an adaptation night sleep from 11 PM to 8 AM: Sleep Deprivation for 27 hours (SD1) with Sleep Recovery (SD2); Alcohol Administration (ALC); Control (CTRL).
Group E will experience the interventions in the following order, following an adaptation night sleep from 11 PM to 8 AM: Alcohol Administration (ALC); Sleep Deprivation for 27 hours (SD1) with Sleep Recovery (SD2); Control (CTRL).
Group D will experience the interventions in the following order, following an adaptation night sleep from 11 PM to 8 AM: Control (CTRL); Sleep Deprivation for 27 hours (SD1) with Sleep Recovery (SD2); Alcohol Administration (ALC).
Group C will experience the interventions in the following order, following an adaptation night sleep from 11 PM to 8 AM: Sleep Deprivation for 27 hours (SD1) with Sleep Recovery (SD2); Alcohol Administration (ALC); Control (CTRL).
Group B will experience the interventions in the following order, following an adaptation night sleep from 11 PM to 8 AM: Alcohol Administration (ALC); Control (CTRL); Sleep Deprivation for 27 hours (SD1) with Sleep Recovery (SD2).
Group A will experience the interventions in the following order, following an adaptation night sleep from 11 PM to 8 AM: Control (CTRL); Alcohol Administration (ALC); Sleep Deprivation for 27 hours (SD1) with Sleep Recovery (SD2).
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Pennsylvania
Lead Sponsor
Uniformed Services University of the Health Sciences
Collaborator
Cornell University/Weill Cornell Medical Center
Collaborator
National Aeronautics and Space Administration (NASA)
Collaborator
University of Nevada, Las Vegas
Collaborator
Loma Linda University
Collaborator
University of Florida
Collaborator
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