Therapy Options for Post-Traumatic Stress Disorder

This trial tests different therapy options for people with PTSD who did not improve after their initial treatment. It aims to assess the practicality of offering another round of therapy and to determine which options are most effective. Researchers aim to develop a simple tool to quickly identify individuals who might benefit from a different treatment approach. Suitable candidates have a PTSD diagnosis, have experienced a traumatic event, and are prepared to attend therapy sessions. As an unphased trial, this study provides an opportunity to contribute to the development of more effective PTSD treatments for those requiring alternative options.

The trial does not specify if you need to stop taking your current medications, but you must have been on a stable dose of any psychotropic medication for at least one month before starting the study.

Studies have shown that Cognitive Processing Therapy (CPT) is safe and well-tolerated for people with PTSD. Research indicates its effectiveness in various settings, such as in-person and online sessions, without requiring extra preparation. Most people can begin treatment immediately, and it is often tailored to individual needs.

Program evaluations, particularly with military and veteran patients, have demonstrated that CPT can help reduce PTSD symptoms and depression. This supports its safety and effectiveness across different groups.

Researchers are excited about Skills Training for Affective and Interpersonal Regulation (STAIR) because it offers a fresh approach to treating PTSD by focusing on emotional and interpersonal skills rather than just processing traumatic memories. Unlike traditional treatments like Cognitive Behavioral Therapy (CBT) or Eye Movement Desensitization and Reprocessing (EMDR), STAIR emphasizes building emotional regulation and improving relationships, which are often affected by PTSD. This approach could be particularly beneficial for those who haven't found relief with standard therapies, providing a more comprehensive way to manage PTSD symptoms. By addressing the emotional and social aspects of PTSD, STAIR has the potential to enhance overall well-being and recovery.

Research has shown that Cognitive Processing Therapy (CPT), which all participants in this trial will initially receive, helps reduce PTSD symptoms. Studies have found that CPT can lead to significant improvements, with patients noticing a clear decrease in their symptoms. In one study, PTSD scores dropped by an average of 14 points, and few people discontinued the treatment early. Another study demonstrated that CPT was more effective than other treatments for easing PTSD symptoms. This evidence suggests that CPT is a dependable option for managing PTSD.²⁴⁶⁷⁸