Cognitive Processing Therapy for Post-Traumatic Stress Disorder

CH
Overseen ByCara Herbitter, PhD, MPH
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Boston University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to enhance treatment for Post-Traumatic Stress Disorder (PTSD) by adapting Cognitive Processing Therapy (CPT), a well-established PTSD therapy. Researchers will test a new version called CPT-LEAP, which includes additional support for stress from lived experiences, particularly for individuals facing health disparities. Participants will receive either the standard CPT or the adapted CPT-LEAP in weekly sessions. Suitable candidates have a PTSD diagnosis, identify as a sexual or gender minority, and live in Massachusetts, while also experiencing stress related to their identity. As an unphased trial, this study offers participants the opportunity to contribute to innovative therapy adaptations that could improve PTSD treatment for diverse communities.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that Cognitive Processing Therapy (CPT) is a well-accepted treatment for post-traumatic stress disorder (PTSD). Studies have found that CPT effectively lessens symptoms of PTSD, depression, and anxiety. It is considered a top treatment, widely used and trusted.

The new version, Cognitive Processing Therapy - Lived Experience Adaptation (CPT-LEAP), builds on this trusted method. Although specific safety data on CPT-LEAP is not yet available, its foundation on standard CPT suggests it should be similarly well-accepted. Previous studies of CPT have demonstrated that it helps many people, though results can vary.

In summary, while more information on CPT-LEAP is needed, existing evidence suggests that treatments based on Cognitive Processing Therapy are generally safe and can be helpful for PTSD.12345

Why are researchers excited about this trial?

Researchers are excited about these treatments because they offer innovative adaptations to traditional cognitive processing therapy (CPT) for post-traumatic stress disorder (PTSD). The Cognitive Processing Therapy - Lived Experience Adaptation Protocol (CPT-LEAP) is particularly unique because it incorporates lived experiences into the therapy process, which may resonate more with patients and lead to better engagement and outcomes. This adaptation is delivered in a variable-length format, which can be tailored to individual needs, potentially offering a more personalized approach compared to the standard CPT. By integrating these new elements, researchers hope to improve the effectiveness of PTSD treatments and provide more meaningful support to those affected.

What evidence suggests that this trial's treatments could be effective for post-traumatic stress disorder?

Studies have shown that Cognitive Processing Therapy (CPT) effectively reduces symptoms of post-traumatic stress disorder (PTSD) and helps lower depression and related issues like panic disorders. Research indicates that CPT can enhance the quality of life and mental health for people with PTSD. In this trial, participants will receive either the standard CPT or the adapted version, CPT-LEAP, which addresses additional stress from personal experiences. While researchers continue to gather specific data on CPT-LEAP, the proven success of CPT suggests that its adaptations could also benefit diverse groups.678910

Who Is on the Research Team?

CH

Cara Herbitter, PhD, MPH

Principal Investigator

Psychiatry CABUSM and National Center for PTSD, VA Boston Healthcare System

Are You a Good Fit for This Trial?

This trial is for people diagnosed with post-traumatic stress disorder (PTSD), especially those from groups who face extra life stresses or health disparities. Participants should be adults able to take part in therapy sessions.

Inclusion Criteria

Endorsement of SGM stress experiences with moderate distress
Self-identification as a sexual or gender minority (SGM) individual
I have been on the same dose of psychiatric medication for at least one month.
See 2 more

Exclusion Criteria

Current severe substance use that warrants immediate medical attention
Current active suicidal or homicidal ideation with intent or plan
I do not have an unstable psychotic disorder or current psychosis.
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Phase 1 - Beta Testing

Refinement and beta testing of Cognitive Processing Therapy Lived Experience Adapted Protocol (CPT-LEAP) with 6 participants

Variable

Phase 2 - Treatment

Pilot RCT with participants randomized to either standard CPT or CPT-LEAP, receiving weekly one-hour sessions for 9-15 weeks

9-15 weeks

Follow-up

Participants are monitored for PTSD symptom severity using CAPS-5 immediately after treatment and at 3 months

3 months

What Are the Treatments Tested in This Trial?

Interventions

  • Cognitive Processing Therapy (CPT)
  • Cognitive Processing Therapy - Lived Experience Adaptation (CPT-LEAP)

Trial Overview

The study compares standard Cognitive Processing Therapy (CPT) with a new version called CPT-LEAP, which adds support for dealing with ongoing life stress. Both are talk therapies aimed at helping PTSD symptoms.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Cognitive Therapy Processing Therapy - Lived Experience Adapted Protocol (CPT--LEAP)Experimental Treatment1 Intervention
Group II: Standard Cognitive Therapy Processing (CPT)Active Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Boston University

Lead Sponsor

Trials
494
Recruited
9,998,000+

National Institute of Mental Health (NIMH)

Collaborator

Trials
3,007
Recruited
2,852,000+

Citations

and Memory-Processing Group Intervention for PTSD ... - PMC

Results revealed significant reductions in: PTSD, complex features of PTSD, and depression, along with improvements in process measures of maladaptive ...

Adapted Cognitive Processing Therapy for PTSD (CPT ...

Both individual and group formats of CPT led to reductions in depression and suicidal ideation, but about 50% of participants still experienced PTSD symptoms ...

Patricia A. Resick | Scholars@Duke profile: Scholarly Works

Benchmarking quality of life to posttraumatic stress disorder symptom changes in cognitive ... THE EVOLUTION OF COGNITIVE PROCESSING THERAPY FOR POST-TRAUMATIC ...

Practice of Cognitive Processing Therapy in Arab ...

Taken together, the three clinical studies consistently reported improvements following CPT, particularly in PTSD symptoms (ElBarazi, 2023; ...

Ask the Clinicians! Real-life Choices in Evidence-Based ...

Research Impression: Massed or intensive models of PTSD treatment are effective and may improve retention and treatment completion10 compared to ...

Effectiveness of Prolonged Exposure Therapy vs. Cognitive ...

recent data has revealed concerning statistics: 29.3% screening positive for PTSD, 26.3% reporting suicidal thoughts, and 26% experiencing substance use ...

Cognitive Processing Therapy Versus Medication for the ...

They found that CPT reduced symptoms of PTSD, depression, anxiety and substance abuse.

Variable-Length Cognitive Processing Therapy for Combat ...

However, 27% still met diagnostic criteria for PTSD after 12 sessions but improved with additional treatment. Three months after treatment, only 2 of the 50 ...

Developmentally Adapted Cognitive Processing Therapy ...

To evaluate the feasibility and efficacy of Developmentally Adapted CPT (D-CPT), we treated 12 adolescents suffering from PTSD secondary to CSA or CPA. Patients ...

List of studies - Ptsd.va.gov - Veterans Affairs

A randomized clinical trial to dismantle components of cognitive processing therapy for posttraumatic stress disorder in female victims of interpersonal ...