40 Participants Needed

Augmented Reality-Enhanced Exposure Therapy for PTSD

AJ
KG
Overseen ByKathleen Gorski, LMSW
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Wayne State University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores a new method to assist military personnel with PTSD by incorporating augmented reality (AR) into traditional exposure therapy. The goal is to determine if wearing AR goggles during therapy improves results and satisfaction compared to traditional therapy alone. Participants will be divided into two groups: one will receive traditional therapy with AR, and the other will receive traditional therapy only. This trial seeks U.S. military veterans or active-duty members with PTSD who do not have serious vision problems. As an unphased trial, it offers participants the chance to contribute to innovative research that could enhance PTSD treatment options.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that augmented reality exposure therapy is safe for PTSD treatment?

Research has shown that augmented reality exposure therapy (ARET) is a promising treatment for PTSD. Studies have found that virtual and augmented reality treatments can be as effective as other therapies and often outperform waiting for treatment. This indicates that ARET is generally well-tolerated.

In specific cases, such as the augmented reality 3MDR therapy, ongoing trials have not reported serious side effects. Patients have managed the treatment without major problems. This innovative technology helps patients gently confront real-world situations they avoid due to trauma.

Since this trial is in the "Not Applicable" phase, researchers are still exploring how well ARET works. This phase focuses more on effectiveness than safety. However, the absence of major negative effects in similar studies provides some reassurance about its safety.12345

Why are researchers excited about this trial?

Researchers are excited about the use of Augmented Reality-Enhanced Exposure Therapy for PTSD because it adds an innovative twist to traditional exposure therapy by incorporating augmented reality (AR) goggles. This new approach immerses patients in controlled, virtual scenarios that closely mimic real-life situations, potentially enhancing the therapy’s effectiveness and engagement. Unlike standard treatments that rely solely on real-world exposure, the AR component allows for a customizable and safe environment for patients to confront their fears. This could lead to quicker symptom reduction and a more tailored therapy experience for nonresponders.

What evidence suggests that augmented reality exposure therapy could be effective for PTSD?

Research shows that augmented reality can enhance the effects of traditional exposure therapy for PTSD. In this trial, one group will receive Traditional Exposure Therapy (ET) alone, while another group will receive it with an Augmented Reality (AR) component. Studies indicate that virtual and augmented reality treatments are often as effective as other active therapies for PTSD. They have been proven more effective than no treatment, allowing patients to see improvements faster. Augmented reality creates lifelike scenarios, helping patients confront their fears in a safe environment. This approach can improve patient responses to therapy, potentially benefiting those who don't initially respond to traditional methods.12467

Who Is on the Research Team?

RA

Ron Acierno, PhD

Principal Investigator

Ralph H. Johnson VA Health Care System

Are You a Good Fit for This Trial?

This trial is for U.S. military personnel, both veterans and active-duty, over the age of 18 who have been diagnosed with PTSD. They must have a confirmed diagnosis through a specific clinical interview (CAPS-5).

Inclusion Criteria

I am over 18 and have served or am serving in the military.
I have been diagnosed with PTSD by a professional using the CAPS-5.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive 10 sessions of 60-minute exposure therapy, either with augmented reality (ARET) or traditional exposure therapy (ET), over 5-10 weeks

5-10 weeks
10 visits (in-person)

Follow-up

Participants are monitored for changes in PTSD symptoms and social functioning after treatment

6 months

What Are the Treatments Tested in This Trial?

Interventions

  • Stepwise Augmented Reality (AR) Component with Traditional Exposure Treatment for Nonresponders
  • Traditional Exposure Therapy (ET) Treatment
Trial Overview The study compares traditional exposure therapy (ET) for PTSD with an advanced version that includes augmented reality (ARET + ET). Participants are randomly assigned to one of two groups to see which method improves clinical and psychosocial functioning.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Traditional Exposure Therapy (ET) Treatment with addition of Augmented Reality (AR) ComponentExperimental Treatment1 Intervention
Group II: Traditional Exposure Therapy (ET) TreatmentActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Wayne State University

Lead Sponsor

Trials
318
Recruited
111,000+

United States Department of Defense

Collaborator

Trials
940
Recruited
339,000+

Ralph H. Johnson VA Health Care System

Collaborator

Trials
1
Recruited
40+

Ralph H. Johnson VA Medical Center

Collaborator

Trials
21
Recruited
5,700+

Citations

Unreal that feels real: artificial intelligence-enhanced ...AI-driven augmented reality exposure therapy (ARET) offers a unique opportunity for in vivo exposure therapy for PTSD by incorporating realistic ...
Review article Efficacy of immersive PTSD treatments: A ...Virtual/Augmented reality exposure therapy (V/ARET) may enhance PTSD treatment. VRET outperformed waitlist control and matched other active psychotherapies.
NCT06740487 | Advanced Wireless Augmented Reality- ...The goal of this trial is to test how augmented reality exposure therapy (ARET) may potentiate the effects of traditional exposure therapy administered to ...
Augmented Reality 3MDR Therapy for the Treatment of ...This case study is part of an ongoing randomized control trial, the first of its kind, evaluating the effectiveness of augmented reality.
a randomized clinical trial of virtual reality and imaginal ...We tested the efficacy of virtual reality exposure (VRE) or prolonged imaginal exposure (PE), augmented with D-cycloserine (DCS) for combat-related PTSD.
Advanced Wireless Augmented Reality-Enhanced ...The goal of this trial is to test how augmented reality exposure therapy (ARET) may potentiate the effects of traditional exposure therapy ...
Unreal that feels real: Pioneering technology developed at ...This technology specifically focuses on avoidances of the real-world environments the patients with PTSD are avoiding due to their trauma, and ...
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