Magnesium + Melatonin for Charley Horse

(MISIT Trial)

This trial aims to determine if a supplement containing magnesium and melatonin can improve sleep quality for adults experiencing nighttime leg cramps. Participants will take either the supplement or a placebo each night for six weeks. Eligible participants must experience at least four leg cramp episodes every two weeks and have poor sleep quality. They will wear an Oura Ring for sleep tracking and complete brief app-based questionnaires, all from home. As an unphased trial, this study provides a unique opportunity to contribute to research that could enhance sleep quality for many.

Yes, you must stop taking any prescription medications to participate in this trial.

Research has shown that magnesium and melatonin supplements are usually safe for most people. Magnesium, a mineral, helps muscles and nerves function properly and is often used in supplements without causing side effects. Melatonin, a hormone, aids in better sleep, and many people use it to improve sleep quality, with side effects being rare. Some individuals might experience slight drowsiness or dizziness, but this is uncommon.

Researchers are excited about using magnesium and melatonin for treating charley horse cramps because these ingredients offer a new approach compared to current treatments like stretching, hydration, or over-the-counter medications. Magnesium helps relax muscles and improve nerve function, while melatonin is known for its sleep-regulating properties, potentially offering dual benefits for nighttime cramps. This combination could provide a more holistic solution by addressing both the muscle and sleep aspects of the condition, making it a promising option for those who experience frequent nocturnal leg cramps.

Research suggests that magnesium may help with muscle cramps by relaxing muscles and blocking calcium, which aids in muscle relaxation. However, some studies have shown that magnesium alone might not be very effective for leg cramps. Melatonin, often used to aid sleep, could improve sleep quality even in the presence of cramps. This trial will test a combination of magnesium and melatonin in a multi-ingredient dietary supplement, potentially addressing both muscle relaxation and improved sleep. Many people have reported that magnesium supplements help reduce cramps and enhance sleep. By combining magnesium and melatonin, this supplement might offer a dual benefit for those experiencing leg cramps at night. Participants in this trial will receive either the magnesium and melatonin supplement or a placebo.⁶⁷⁸⁹¹⁰