45 Participants NeededMy employer runs this trial

Sleep Restriction for High Blood Pressure

JL
Overseen ByJacqueline Limberg
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how reduced sleep might affect high blood pressure. Participants will either limit their sleep to four hours (sleep restriction) or maintain a normal sleep schedule of 7-9 hours. The trial aims to understand the link between sleep and changes in blood pressure. Healthy adults who usually sleep 7-9 hours per night and have no history of high blood pressure or other major health issues may be suitable candidates.

As an unphased trial, this study allows participants to contribute to important research on sleep and health without the risks associated with new treatments.

Will I have to stop taking my current medications?

Yes, you must not be taking any medications that affect sleep, metabolism, or heart function to participate in this trial.

What prior data suggests that sleep restriction is safe for individuals with high blood pressure?

Research has shown that insufficient sleep can affect blood pressure. Some studies suggest that sleeping less might cause blood pressure to rise. For instance, one study found that people who sleep less may experience higher blood pressure, while another study found that insufficient sleep can raise blood pressure at night. However, other research did not find a strong connection between less sleep and changes in blood pressure, indicating that more studies are needed for a clearer understanding.

In summary, while insufficient sleep might influence blood pressure, the extent of these effects remains unclear. No major safety concerns have been reported specifically about sleep restriction. However, losing sleep might impact health and well-being in other ways. Always consult a healthcare provider if there are concerns about joining a study that involves changes to sleep patterns.12345

Why are researchers excited about this trial?

Researchers are excited about the sleep restriction trial for high blood pressure because it explores a non-drug approach that could offer a new way to manage blood pressure. Unlike standard treatments that typically involve medications like ACE inhibitors or beta-blockers, this approach investigates how reducing sleep to just four hours might impact blood pressure levels. This study could reveal important insights into the role of sleep duration in cardiovascular health, potentially leading to innovative lifestyle-based interventions for managing high blood pressure.

What evidence suggests that sleep restriction is effective for high blood pressure?

Research has shown that insufficient sleep can affect blood pressure. Studies have found that both men and women tend to experience higher blood pressure when they lack adequate sleep. For instance, one study discovered that reduced sleep led to increased blood pressure both during the day and at night, particularly in women. Another study indicated that less sleep is linked to a higher risk of developing high blood pressure. This trial will compare the effects of sleep restriction, where participants will shorten their sleep to four hours, with normal sleep, where participants will sleep for 7-9 hours. These findings suggest that insufficient sleep can raise blood pressure, emphasizing the importance of adequate rest for maintaining healthy blood pressure.678910

Are You a Good Fit for This Trial?

This trial is for healthy men and women aged 18-45 who are either normal weight or have obesity, sleep 7-9 hours a night with bedtime before midnight, are premenopausal (if female), not pregnant or breastfeeding, don't use nicotine, and have no major health conditions or sleep disorders.

Inclusion Criteria

BMI < 25 kg/m² (normal weight group) or ≥ 30 kg/m² (obesity group)
I am a healthy adult.
Self-reported history of normal sleep duration (7-9 hours/night) and bedtime prior to midnight
See 3 more

Exclusion Criteria

I am not taking any medicines that affect sleep, heart, metabolism, or nerves.
Self-reported history of irregular sleep
I have a history of serious organ disease, sleep issues, diabetes, or substance abuse.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants undergo sleep restriction or maintain normal sleep patterns

4 weeks
Weekly check-ins (virtual)

Follow-up

Participants are monitored for blood pressure reactivity after sleep intervention

2 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Sleep Restriction

Trial Overview

The study tests how getting less sleep than usual affects blood pressure. Participants will undergo periods of restricted sleep to see its impact on their blood pressure responses.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Sleep RestrictionExperimental Treatment1 Intervention
Group II: Normal SleepActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Missouri-Columbia

Lead Sponsor

Trials
387
Recruited
629,000+

Citations

Effect of behavioural sleep interventions on blood pressure ...

Using behavioural sleep interventions led to clinically significant reductions in blood pressure, suggesting addressing poor sleep health could feature in blood ...

Sleep Duration and Blood Pressure: Recent Advances ... - PMC

Observational studies indicate that short and long sleep are associated with hypertension risk, reduced nocturnal dipping, and elevated morning BP.

Sleep Duration and Hypertension: Epidemiological Evidence ...

A study from the Carter laboratory reported 24 hours of sleep deprivation increased blood pressure but reduced sympathetic tone in young healthy men with no ...

Effects of Experimental Sleep Restriction on Ambulatory ...

We investigated the effects of prolonged sleep restriction on 24-hour ambulatory blood pressure (BP) and other cardiovascular measures in 20 healthy young ...

Effects of Experimental Sleep Restriction on... : Hypertension

Post hoc analysis revealed that 24-hour BP, wakefulness, and sleep BP increased during experimental and recovery phases of sleep restriction only in women, in ...

The Effect of Sleep Disturbances on Blood Pressure - PMC - NIH

These data demonstrate that repeated exposure to shortened sleep reduces BP dipping, despite intermittent catch-up sleep. Whether frequent shortened sleep may ...

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pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/31455197/

Sleep Restriction Effects on BP: Systematic Review & Meta ...

In this review, we did not find significant effects of sleep restriction on BP or HR measured by cross-sectional methods. More studies are warranted to confirm ...

Can a lack of sleep cause high blood pressure?

People who sleep six hours or less may have steeper increases in blood pressure. If you already have high blood pressure, not sleeping well may make your blood ...

Sleep Restriction and Parental History of Hypertension

The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood ...

Irregular sleep schedule linked to high blood pressure

People whose sleep duration varied by two hours or more from night to night were 85% more likely to have hypertension than those with less than ...