TurbAlign for Sinus Surgery

(Gaia Trial)

Not yet recruiting at 4 trial locations
LI
MS
Overseen ByMargo Snyder
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores a new implant called TurbAlign, designed to assist with sinus surgery. The goal is to determine if this implant can effectively separate parts of the nasal area to aid recovery after surgery. It is ideal for those scheduled for sinus surgery soon and who have not had any major nasal issues or surgeries before. Frequent use of nasal sprays or recent nasal drug use may disqualify participation. As an unphased trial, this study offers a unique opportunity to contribute to innovative research in sinus surgery recovery.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it does exclude people who use nasal decongestants regularly. It's best to discuss your specific medications with the trial team.

What prior data suggests that the TurbAlign device is safe for sinus surgery?

Research shows that the FDA has cleared the TurbAlign implant for use in sinus surgery. This clearance indicates that the device meets specific safety standards. The TurbAlign is a bioabsorbable implant, meaning it breaks down in the body, and it is designed to aid healing by stabilizing nasal structures after surgery.

In earlier studies, researchers used TurbAlign to help position the middle turbinate, a part inside the nose, and patients generally tolerated it well. There were no major reports of serious side effects, suggesting the implant is safe for use in people, although individual experiences may differ. It is important to consult a doctor to understand the potential risks and benefits for your situation.12345

Why are researchers excited about this trial?

TurbAlign is unique because it uses the Spirair device to specifically target the medialization of the middle turbinates during sinus surgery. Unlike traditional treatments for nasal obstruction, which might include medications like nasal steroids or surgical procedures such as turbinate reduction, TurbAlign focuses on repositioning the turbinates more precisely. This novel approach could potentially offer better outcomes by improving airflow and reducing nasal blockage more effectively. Researchers are excited because this method might lead to quicker recovery times and improved comfort for patients undergoing sinus surgery.

What evidence suggests that the TurbAlign device is effective for sinus surgery?

Research has shown that the TurbAlign implant aids sinus surgery by stabilizing the middle turbinate. In one study, 70% of patients in one group and 80% in another experienced complete symptom relief, with no recurrence of sinusitis. The implant dissolves in the body over time, eliminating the need for removal. The FDA has approved TurbAlign, confirming its safety and effectiveness for holding the middle turbinate after surgery. These findings suggest that TurbAlign can be a reliable choice for enhancing sinus surgery outcomes.12356

Are You a Good Fit for This Trial?

This trial is for individuals who have undergone functional endoscopic sinus surgery and are experiencing turbinate hypertrophy, which can cause nasal obstruction. Specific eligibility criteria details were not provided.

Inclusion Criteria

Able to speak, read and understand English
Willing and able to provide informed consent and comply with the study protocol
I am between 18 and 70 years old.
See 1 more

Exclusion Criteria

I have had surgery to remove one or both of my middle turbinates.
Hypersensitivity to any investigational device materials including known or suspected allergy to poly(dioxanone) (PDO) or other bioabsorbable materials
I regularly use nasal decongestants like Afrin.
See 5 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive the Spirair device for medialization of the middle turbinates

8 weeks
Regular visits for device assessment and monitoring

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • TurbAlign
Trial Overview The study is testing the safety and effectiveness of a bioabsorbable implant called TurbAlign™, designed to keep the middle turbinate away from the lateral nasal wall after sinus surgery.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Open-labelExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Spirair, Inc

Lead Sponsor

Trials
2
Recruited
80+

Citations

NCT07027267 | Safety and Effectiveness of TurbAlign™ for ...To evaluate the safety and effectiveness of the Spirair implant as a primary treatment to achieve medialization of the middle turbinate after functional ...
A Comparative Study of Interventions of Middle Turbinate ...70% of the patients in Group A and 80% of patients in Group B had complete improvement in symptoms with no recurrence of sinusitis compared to Group C in which ...
FDA OKs Spirair's TurbAlign Resorbable Sinus Surgery ...The implant provides secure middle turbinate medialization, then resorbs without needing removal. Jayakar Nayak, MD, Ph.D., Associate Professor ...
TurbAlign for Sinus Surgery · Info for ParticipantsTrial Overview The study is testing the safety and effectiveness of a bioabsorbable implant called TurbAlign™, designed to keep the middle turbinate away from ...
Safety and Effectiveness of TurbAlign™ for Middle Turbinate ...A study of a bioabsorbable implant to separate the middle turbinate from the lateral nasal wall associated with nasal/sinus surgery.
July 11, 2025 Spirair, Inc Tracey Henry VP Clinical Affairs ...TurbAlign™ is a bioabsorbable, polydioxanone implant designed to hold the middle turbinate away from the lateral nasal wall during the ...
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