Brain Stimulation for Cannabis Craving in Schizophrenia

This trial tests a brain stimulation technique, Precision Brain Stimulation, to determine if it can reduce cannabis cravings and improve cognitive skills in individuals with schizophrenia or schizoaffective disorder. The researchers aim to discover whether stimulating specific brain areas can alter brain activity and behavior differently in those with schizophrenia compared to healthy cannabis users. Suitable participants include current cannabis users who either have schizophrenia or schizoaffective disorder, or are healthy cannabis users. The study seeks to lay the groundwork for future treatments that better address cannabis cravings in these groups. As an unphased study, it offers participants the chance to contribute to groundbreaking research that could lead to innovative treatments for cannabis cravings.

The trial does not specify if you must stop taking your current medications. However, your medications will be reviewed by a physician to decide if you can participate, considering your medical history and any recent changes in medication.

Studies have shown that precision brain stimulation, specifically repetitive transcranial magnetic stimulation (rTMS), is generally safe. Research indicates that rTMS applied to the DLPFC, a part of the brain, is well-tolerated by people with schizophrenia who use cannabis, meaning most do not experience serious side effects.

The Safety of TMS Consensus Group examined the risks and found no additional major adverse events in specific patients. This finding suggests the treatment is safe for many.

Researchers are excited about the use of precision brain stimulation for addressing cannabis cravings in individuals with schizophrenia because it offers a novel approach compared to traditional treatments like antipsychotic medications and cognitive behavioral therapy. Unlike these standard methods, precision brain stimulation directly targets specific brain areas involved in craving and addiction, potentially offering more immediate and targeted relief. This technique also holds promise in minimizing side effects typically associated with medication, paving the way for a more personalized and effective treatment strategy.

Research has shown that repetitive transcranial magnetic stimulation (rTMS) can significantly reduce cannabis use in people with schizophrenia who experience strong cravings. One study found that rTMS decreased self-reported cannabis use by up to 60% in this group. This suggests that brain stimulation might manage cravings by altering brain activity. In this trial, participants will receive Precision Brain Stimulation, targeting specific brain areas related to cravings and cognitive functions. Overall, these findings are promising for using brain stimulation to help people with schizophrenia reduce cannabis use.¹⁶⁷⁸⁹