Laser Retinopexy for Stickler Syndrome

(OSC/SS Trial)

This trial aims to evaluate the effectiveness of a laser procedure in preventing retinal detachment in individuals with Stickler Syndrome (SS), a genetic condition that can cause serious vision problems. Participants will receive a non-invasive laser treatment called Prophylactic Laser Retinopexy in one or both eyes and will undergo regular eye tests over five years to monitor outcomes. This study is open to individuals diagnosed with Stickler Syndrome type 1 or 2 through genetic testing. As an unphased trial, it offers participants the chance to contribute to groundbreaking research that could enhance future treatment options for Stickler Syndrome.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial team or your doctor.

Research shows that the laser treatment under study, called prophylactic laser retinopexy, is usually well-tolerated. This treatment can significantly reduce the risk of retinal detachment in people with Stickler Syndrome. Simply put, it helps keep the retina, the part of the eye that senses light, in place, which is crucial for maintaining clear vision.

While some studies show strong benefits, not all agree on its effectiveness. However, substantial evidence suggests it can help prevent retinal issues without causing major side effects.

Researchers are excited about prophylactic laser retinopexy for Stickler Syndrome because it offers a non-invasive approach to potentially prevent retinal detachment, a common complication of the condition. Unlike traditional surgical methods, this laser treatment is less invasive and aims to strengthen the retina by creating small, controlled burns to form scar tissue, securing it in place. This could significantly reduce the risk of vision loss without the need for more intrusive procedures, making it a promising option for children, adolescents, and adults with Stickler Syndrome.

Research has shown that prophylactic laser retinopexy can significantly reduce the risk of retinal detachment in individuals with Stickler Syndrome. This trial will administer the laser treatment to participants to assess its effectiveness. One study found that patients who received this treatment were much less likely to experience retinal detachment than those who did not. Another study reported that eyes treated with laser retinopexy had vision approximately eight lines better on an eye chart compared to untreated eyes. Additionally, this laser treatment was associated with a 93% decrease in the likelihood of retinal detachment. These findings suggest that laser retinopexy effectively prevents retinal problems in people with Stickler Syndrome.¹²⁴⁶⁷