Probiotic Capsule for Vitamin Levels

(PROSPER Trial)

This trial explores whether a probiotic capsule can boost levels of vitamins B12, B6, and folate in women of childbearing age. Participants will take either a high or low dose of the probiotic daily for four weeks and provide blood and stool samples to assess the effect. Women living in Ontario who are not taking B vitamin supplements or probiotics and have no gastrointestinal issues may be suitable candidates. The trial aims to determine if probiotics can naturally enhance important vitamin levels in the body. As an unphased trial, this study offers a unique opportunity to contribute to the scientific understanding of probiotics' effects on vitamin levels.

The trial does not specify if you need to stop taking your current medications, but you cannot take any B-vitamin supplements or probiotics during the study. If you're using these, you'll need to stop before joining.

Research has shown that probiotics have been used safely for many years. In studies, participants taking probiotics reported only minor issues like stomach cramps, nausea, and gas. These side effects are usually mild and uncommon.

Most probiotics are considered safe for healthy individuals. Although there have been some reports of serious problems, these are rare and typically occur in people with weakened immune systems.

Most treatments for boosting vitamin levels typically involve dietary supplements or fortified foods. However, the probiotic capsule under study is unique because it uses live beneficial bacteria to potentially enhance vitamin absorption naturally in the gut. Researchers are excited about this approach since it taps into the body's natural processes, potentially offering a more sustainable and holistic method of increasing vitamin levels. Unlike traditional supplements, these probiotics could improve gut health while delivering vitamins, offering a dual benefit. The study is also exploring different doses, which might provide insights into optimizing effectiveness and safety.

Research shows that probiotics can boost certain vitamin levels in the blood. Specifically, studies have found that taking probiotics can raise vitamin B12 and folate levels. However, strong evidence does not support an effect on vitamin B6 levels. Probiotics, which are live bacteria, can also support overall health, including the immune system. This support might help the body absorb and use vitamins more effectively. In this trial, participants will receive either a high dose or a low dose of a probiotic product in capsule form to evaluate its impact on vitamin levels.⁶⁷⁸⁹¹⁰