Nextida-GC + Whey Protein for Prediabetes

This trial tests whether Nextida-GC, a peptide from collagen, can lower blood sugar levels after eating, compared to whey protein. The researchers aim to determine if taking these supplements 30 minutes before, 10 minutes before, or with a meal is more effective. Individuals with prediabetes or normal blood sugar levels might be suitable candidates, particularly if they can commit to multiple visits at a research center and are comfortable eating study meals. As an unphased trial, it offers participants the chance to contribute to groundbreaking research on dietary supplements and blood sugar management.

The trial information does not specify if you need to stop taking your current medications. However, you cannot use supplements containing collagen or high doses of chromium, and any drug use that might affect the results is not allowed. It's best to discuss your specific medications with the trial team.

Research shows that both Nextida-GC and whey protein are generally safe and well-tolerated. Nextida-GC, a peptide derived from collagen, has been found to significantly boost the natural release of GLP-1, a hormone that helps control blood sugar levels. In one study, participants who took either 5 or 10 grams of Nextida-GC experienced an average 42% reduction in blood sugar spikes after eating, indicating effective treatment without major side effects.

Whey protein has undergone extensive study and is considered safe to consume. Research indicates that whey protein can lower blood sugar levels after meals, aiding in blood sugar control. It has been linked to improved blood sugar and insulin response without major negative effects.

Researchers are excited about these treatments for prediabetes because they explore the timing of whey protein intake in relation to meals. Unlike most conventional treatments like lifestyle changes, metformin, or other medications that primarily focus on blood sugar regulation after meals, this approach investigates how pre-meal protein timing can influence glucose levels. The unique aspect here is the potential to control blood sugar spikes by consuming protein 30 minutes, 10 minutes, or at the start of a meal. This method could offer a simple, dietary-based strategy to manage prediabetes, which might be more accessible and have fewer side effects than traditional drugs.

This trial will compare the effects of Nextida-GC and whey protein on blood sugar management in individuals with prediabetes. Studies have shown that Nextida-GC, a component of collagen, increases GLP-1, a hormone that aids in sugar management. Whey protein slows the rate at which food leaves the stomach and increases insulin, thereby lowering blood sugar levels. Research indicates that whey protein can reduce blood sugar spikes by about 1.0 mmol/L. Both treatments show promise for managing blood sugar, but further testing in this trial will determine which one is more effective.¹²³⁴⁶