CGM-Enhanced DPP for Prediabetes

(CGM-DPP Trial)

This trial explores whether combining continuous glucose monitoring (CGM) with the Diabetes Prevention Program (DPP) can help people with prediabetes adhere more effectively to healthy lifestyle changes. Prediabetes, a condition where blood sugar levels are higher than normal but not yet classified as diabetes, increases the risk of developing type 2 diabetes and heart disease. The trial compares two groups: one uses CGM devices with coaching, while the other follows the standard DPP without CGM. Eligible participants have been diagnosed with prediabetes and are willing to use CGM devices and attend coaching sessions. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could enhance diabetes prevention strategies.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that continuous glucose monitoring (CGM) is generally safe for people with diabetes. Studies indicate that CGM users often achieve better blood sugar control and feel more satisfied with their diabetes management. Although less information exists on CGM use for prediabetes, its success with diabetes suggests potential benefits. The technology is approved for diabetes management, indicating a strong safety record. Most people tolerate CGM well, with few reports of serious side effects. Some users might experience mild skin irritation at the attachment site, but this is usually easy to manage.¹²³⁴⁵

Researchers are excited about the CGM-Enhanced Diabetes Prevention Program (DPP) for prediabetes because it combines traditional lifestyle changes with modern technology, potentially offering a more personalized approach to managing blood sugar levels. Unlike standard options, which generally involve only lifestyle and dietary changes, this method uses Continuous Glucose Monitors (CGMs) to provide real-time feedback and coaching. This allows individuals to see the immediate impact of their lifestyle choices on their blood sugar, promoting more effective and sustained behavioral changes. By integrating technology with health coaching, this approach could lead to more successful prevention of diabetes progression.

This trial will compare the effectiveness of the Diabetes Prevention Program (DPP) alone with the DPP enhanced by continuous glucose monitors (CGM) and coaching. Research has shown that using a CGM with the DPP can effectively manage prediabetes. Studies have found that CGM helps people understand how diet and exercise affect blood sugar, encouraging healthier choices. Real-time CGM with digital coaching has improved blood sugar control in those with prediabetes. Additionally, research indicates that the lifestyle changes encouraged by the DPP can significantly lower the risk of developing type 2 diabetes. Combining these methods may help people maintain healthy habits long-term and improve overall health outcomes.¹⁴⁵⁶⁷