sFlt-1/PlGF for Pre-eclampsia
(DISPATCH Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This pilot study tests the feasibility of conducting an interventional study in pregnant people with chronic hypertension with interventional clinical management based on sFlt-1/PlGF. It will also collect data on time to delivery, the incidence of preterm delivery, and other maternal or neonatal complications, for a pivotal trial.
Who Is on the Research Team?
Juan M Gonzalez Velez, MD PhD
Principal Investigator
University of California, San Francisco
Are You a Good Fit for This Trial?
This trial is for pregnant people who have chronic high blood pressure. It aims to see if using a specific lab test (sFlt-1/PlGF) can help guide care and possibly prevent preeclampsia or related complications.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Trial Overview
The study compares usual care versus adjusting pregnancy management based on results from the sFlt-1/PlGF blood test, which may help predict risk of preeclampsia. Participants are randomly assigned to either group.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
The clinical team will receive qualitative assay results normal (sFlt-1/PlGF \<40) or abnormal (sFlt-1/PlGF ³40)) and the ratio value and concentrations of PlGF and sFlt-1.
The clinical team will be blinded to assay results and will manage as per their usual clinical protocol.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, San Francisco
Lead Sponsor
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