Ren-Nu + KetoCitra for Polycystic Kidney Disease

(PKD-KETO Trial)

This trial aims to evaluate the effects of a ketogenic diet called Ren-Nu, combined with a supplement called KetoCitra, on individuals with autosomal dominant polycystic kidney disease, a genetic disorder characterized by cysts on the kidneys. Researchers will provide nutritional counseling and instruct participants on following this specific diet plan. Individuals diagnosed with this kidney condition, who have a BMI of 25 or higher, and can manage their blood pressure at home may be suitable candidates. As an unphased trial, this study offers a unique opportunity to explore innovative dietary approaches for managing kidney disease.

You may need to stop taking certain medications if they could affect safety or compliance with the study. These include medications like KetoCitra, urine alkalizing agents, and some others. It's best to discuss your current medications with the trial team to see if any changes are needed.

Research has shown that ketogenic diets, such as Ren-Nu and KetoCitra, are generally safe for individuals with autosomal dominant polycystic kidney disease (ADPKD). In studies, 66% of participants experienced common side effects, and 22% reported concerns like high cholesterol. However, 92% found the diet manageable.

Unlike the standard of care for polycystic kidney disease, which typically involves managing symptoms with blood pressure medications and sometimes dialysis or kidney transplant, Ren-Nu offers a novel approach. Researchers are excited about these treatments because Ren-Nu, combined with the KetoCitra supplement, leverages a ketogenic diet to potentially slow down kidney cyst growth. This dietary strategy focuses on altering metabolism, which is a fresh angle compared to traditional methods that do not directly target metabolic pathways. By addressing the disease's root causes through nutrition, Ren-Nu could offer a non-invasive, holistic alternative to managing polycystic kidney disease.

Studies have shown that ketogenic diets can benefit people with polycystic kidney disease (ADPKD). In earlier research, 67% of participants reported improvements in health issues related to ADPKD, and 90% experienced significant weight loss. Another study found that a ketogenic diet slowed kidney growth, which is important because it can mean less damage over time. In animal studies, ketogenic diets also reduced kidney size and improved kidney function. This trial will evaluate the effects of a ketogenic diet, as part of the Ren-Nu program, combined with the KetoCitra supplement, to determine if it might help manage ADPKD symptoms and slow its progression.¹²³⁶⁷