Exercise for Cognitive Health in Perimenopause

(EPIC Trial)

This trial explores how exercise can benefit brain health in women undergoing perimenopause, the transition period before menopause. Researchers aim to determine if resistance training, such as lifting weights, can enhance thinking abilities and overall well-being. Participants are women aged 40 to 55 who have recently noticed memory or thinking challenges and are not already engaged in regular strength training. The trial will compare progressive resistance training, which involves gradually increasing weights, to exercises focused on balance and flexibility. Women experiencing changes in thinking who wish to try exercise as a potential solution may find this study suitable. As an unphased trial, it offers a unique opportunity to explore innovative exercise solutions for cognitive health during perimenopause.

If you are taking medications that negatively affect cognitive function, such as anticholinergics, major tranquilizers, and anticonvulsants, you may not be eligible for the trial. The protocol does not specify if you need to stop other medications, so it's best to discuss your specific situation with the trial coordinators.

Research has shown that progressive resistance training (PRT) is generally safe and well-tolerated. Studies have found that older adults who engage in resistance training can improve muscle strength and brain function. In one small study involving women going through menopause, resistance training reduced feelings of depression and anxiety, indicating benefits for mental health. These studies reported no major negative effects, meaning participants did not experience serious problems from the training.

Most treatments for cognitive health during perimenopause focus on hormone therapy or medications targeting symptoms. Unlike these standard approaches, Progressive Resistance Training (PRT) offers a physical exercise method that strengthens muscles while potentially boosting brain health. Researchers are excited about PRT because it combines physical conditioning with cognitive benefits, offering a holistic approach without relying on pharmaceuticals. This method encourages social interaction through group-based sessions, which may further enhance mental well-being.

This trial will compare Progressive Resistance Training (PRT) with Balance, Flexibility, and Tone Exercises (BAT) for cognitive health in perimenopausal women. Studies have shown that resistance training benefits brain health. Specifically, one study found that participants who engaged in resistance exercises improved their cognitive flexibility, the ability to switch between different thoughts. Research suggests that physical activities like resistance training can support thinking skills during and after menopause. As hormonal changes during menopause can affect brain health, exercise might help counter these effects. Although more research is needed specifically for women experiencing perimenopause, current findings suggest that progressive resistance training could benefit brain health.¹²⁶⁷⁸