Plant-Based Diet for Early Stage Multiple Myeloma

This trial explores whether a plant-based diet can aid individuals who are overweight and have early-stage blood conditions like MGUS or SMM, which could progress to multiple myeloma, a type of cancer. The study will assess participants' adherence to the diet, its impact on weight loss, and its effects on overall quality of life. Additionally, it aims to determine if this diet can prevent the condition from worsening. Suitable candidates include those with a confirmed diagnosis of MGUS or SMM, a BMI of 25 or higher, and an interest in learning plant-based cooking. As an unphased trial, this study presents a unique opportunity to investigate lifestyle changes that could enhance health and prevent disease progression.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that a plant-based diet might be a safe choice for people at risk of developing multiple myeloma. Studies have found that consuming plant-based foods, such as beans, fruits, and vegetables, which are high in fiber, is linked to a lower risk of this condition. Thus, individuals who eat these foods may be less likely to develop multiple myeloma.

Additionally, past trials have suggested that a high-fiber plant-based diet could be beneficial for those at risk, supporting its safety and potential advantages. No evidence indicates serious harm from following a plant-based diet, making it a well-tolerated option for many.

Unlike the standard treatments for early stage multiple myeloma, which often involve chemotherapy, steroids, or immunotherapy, this new approach features a whole-foods plant-based diet. Researchers are excited because this diet emphasizes natural, nutrient-rich ingredients that could improve overall health without the side effects typically associated with drug therapies. Additionally, the inclusion of nutrition counseling offers personalized support, potentially enhancing adherence and effectiveness. This innovative approach might provide a gentler, more holistic way to manage the condition and improve patients' quality of life.

Research suggests that a plant-based diet might slow the progression of conditions like MGUS and SMM to multiple myeloma. Studies have shown that people who primarily consume plants tend to have a lower risk of developing multiple myeloma compared to those who eat meat. A diet high in plant fiber might also benefit those at risk for this cancer type. Healthier eating habits, including more fruits, vegetables, and whole foods, have been linked to lower death rates in multiple myeloma patients. This trial will evaluate the effects of a plant-based diet, as participants will follow a whole-foods plant-based diet for 12 weeks, with nutrition counseling for 24 weeks. Increasing plant-based meals could be a promising way to manage these conditions.²³⁵⁶⁷