Microwave Ablation for Pancreatic and Liver Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a treatment for individuals with advanced pancreatic or liver cancer that cannot be surgically removed. The study employs an EUS-Guided Microwave Ablation Device, which uses microwave energy to shrink tumors, guided by ultrasound. Researchers aim to determine if this method is safe and effective in reducing tumor size. Participants must have a tumor accessible by this method and advanced cancer that has spread or cannot be surgically removed. As an unphased trial, this study provides patients the opportunity to contribute to innovative research that could lead to new treatment options.
What prior data suggests that the EUS-Guided Microwave Ablation Device is safe for treating pancreatic and liver cancer?
Research into the EUS-Guided Microwave Ablation Device for treating liver and pancreatic cancer has shown promising safety results. Although specific data from past studies are not provided, testing in other clinical settings suggests it is safe enough for further evaluation.
Microwave ablation is generally well-tolerated, using heat to target and destroy cancer cells. Some side effects, such as mild pain or fever, may occur but are usually temporary. If the device were unsafe, it likely would not have reached this stage of research. Patients should discuss any concerns with their doctor to ensure this treatment is appropriate for them.12345Why are researchers excited about this trial?
Researchers are excited about this treatment because it uses a microwave ablation device guided by endoscopic ultrasound (EUS) to target pancreatic and liver tumors. Unlike traditional surgery or chemotherapy, which can be invasive or have widespread effects, this method is minimally invasive, offering a precise way to destroy cancer cells with heat. This technique potentially reduces recovery time and minimizes damage to surrounding healthy tissue, making it a promising option for patients who may not tolerate more aggressive treatments.
What evidence suggests that this microwave ablation device is effective for pancreatic and liver cancer?
Research has shown that microwave ablation could be a promising treatment for pancreatic and liver cancer. Earlier studies successfully shrank tumors by using heat to kill cancer cells. This minimally invasive technique directly targets the cancer, helping to protect surrounding healthy tissue. Early results suggest that patients receiving this treatment have good control over their tumors. Although more research is needed, these initial findings offer hope for those with advanced or spreading cancer. Participants in this trial will receive treatment using the EUS-Guided Microwave Ablation Device to further evaluate its effectiveness.678910
Who Is on the Research Team?
Neil Sharma, MD
Principal Investigator
Banner Health (Banner MD Anderson Cancer Center at Gateway Medical Center)
Are You a Good Fit for This Trial?
This trial is for adults with pancreatic, liver, or biliary tract cancer that cannot be removed by surgery or has spread. Participants should have locally advanced or metastatic disease and be able to undergo an endoscopic procedure.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive endoscopic ultrasound-guided microwave ablation (MWA) treatment
Follow-up
Participants are monitored for safety and effectiveness after treatment, including evaluation of antitumor effects and procedural safety
What Are the Treatments Tested in This Trial?
Interventions
- EUS-Guided Microwave Ablation Device
Trial Overview
The study tests a new treatment using an ultrasound-guided microwave ablation (MWA) device to target tumors in the pancreas, liver, or bile ducts. The main goal is to see if the device can safely deliver energy and shrink tumors.
How Is the Trial Designed?
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Treatment groups
Experimental Treatment
This is a open label feasibility study and only eligible participants will be enrolled into the single arm of the study to receive MWA with this specific device.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Banner Health
Lead Sponsor
Creo Medical Limited
Industry Sponsor
CreoMed, Inc.
Industry Sponsor
Citations
Pancreatic cancer - Symptoms and causes
An endoscopic ultrasound, or EUS, is when the doctor passes a tiny camera down the esophagus and into the stomach to get a close-up view of the pancreas.
Asynchronous evolution of epithelium and stroma ... - PubMed
Together, our data show asynchronous evolution of epithelial and stromal components during pancreatic carcinogenesis. Lack of stromal ...
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