NEUROCUPLE™ Patch for Knee Pain

This trial tests a new device called the NEUROCUPLE patch to determine its effectiveness in reducing knee pain and the need for opioids after knee replacement surgery. Researchers aim to assess whether the patch can lessen pain while at rest on the first day after surgery and reduce opioid use during the same period. Participants will receive either the NEUROCUPLE patch or a look-alike placebo patch to wear for 7 days, with their pain levels and medication use monitored. The trial is suitable for adults scheduled for a single knee replacement surgery who do not have other major health issues or surgeries planned. As an unphased trial, this study offers participants the chance to contribute to innovative research that could enhance post-surgical pain management.

The trial information does not specify if you need to stop taking your current medications. However, if you have a severe chronic pain condition that requires daily opioid use, you may not be eligible to participate.

Research has shown that the NEUROCUPLE™ patch appears safe for managing pain after knee surgery. In an earlier study, patients who used the NEUROCUPLE™ patch for three days experienced no local side effects, suggesting it is well-tolerated for short-term use. Designed as a non-drug option for pain relief, it aims to help without the side effects associated with medications like opioids. Overall, findings indicate that the patch could be a safe alternative for managing knee pain without drugs.¹²³⁴⁵

The NEUROCUPLE™ Patch is unique because it introduces a non-invasive, localized method of pain management for knee pain following total knee arthroplasty (TKA). Unlike standard treatments like oral pain medications, which can have systemic side effects, this patch provides targeted relief directly at the site of pain. Researchers are excited about this treatment as it could reduce the need for opioids and their associated risks, offering a safer and potentially more effective option for managing post-surgical knee pain.

Research has shown that the NEUROCUPLE™ patch, which participants in this trial may receive, can help reduce pain after knee surgery. One study found that patients using the patch experienced 34% less pain while resting. Another study discovered that patients required 47% fewer opioid refills in the first 30 days after surgery. These findings suggest that the NEUROCUPLE™ patch could serve as a non-drug option to manage pain and reduce opioid use after knee replacement surgery.¹²³⁶⁷