Ventilation Modes for Children on Mechanical Ventilation
(WOB Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this trial is to learn if one mode of mechanical ventilation (i.e. machine to help with breathing) is better than another in children who need help from a machine to breathe. The main questions it aims to answer are:
* How hard do children need to work to breathe when they are using different types of modes of mechanical ventilation?
* Evaluate which mode of mechanical ventilation performs better when the patient is clinically awake enough to start breaths
Who Is on the Research Team?
Luciana Rodriguez Guerineau, M.D.
Principal Investigator
The Hospital for Sick Children
Are You a Good Fit for This Trial?
This trial is for children in the pediatric intensive care unit (PICU) who need a breathing machine due to conditions like severe asthma. Participants must be awake enough to try starting breaths on their own.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Trial Overview
The study compares two types of ventilator settings—Pressure Support Mode and Pressure Control Mode—to see which helps children breathe more easily when they are using a mechanical ventilator.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
SIMV PC/PS (30 mins) followed by PSV (30 mins) followed by PCV (30 mins)
SIMV PC/PS (30 mins) followed by PCV (30 mins) followed by PSV (30 mins)
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Hospital for Sick Children
Lead Sponsor
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