Empowered Relief for Osteoarthritis

JB
Overseen ByJordan Bernstein
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Cedars-Sinai Medical Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine if a single, 2-hour online class called Empowered Relief can help individuals with advanced osteoarthritis manage pain more effectively. The class imparts skills from cognitive behavioral therapy (CBT), mindfulness, and pain education to alleviate pain and enhance quality of life. The trial compares this innovative approach with standard educational materials for pain management. It suits adults with advanced osteoarthritis who cannot undergo joint replacement surgery due to personal or medical reasons. Participants will attend the class online and have their progress evaluated at three intervals over eight weeks. As an unphased trial, this study provides a unique opportunity to explore innovative pain management techniques without the constraints of traditional clinical trial phases.

Do I have to stop taking my current medications for the trial?

The trial protocol does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your healthcare provider.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that Empowered Relief is a safe method for managing chronic pain. In earlier studies, participants found the Empowered Relief class as effective as attending eight sessions of cognitive behavioral therapy (CBT) for chronic low back pain. Notably, there were no reports of serious side effects or safety issues, indicating that patients tolerate the Empowered Relief approach well.

Empowered Relief is a one-time, online class that teaches skills for pain management. It combines CBT techniques, mindfulness, and pain education into a short session. Participants have managed their pain and improved their quality of life without experiencing negative side effects.

Overall, Empowered Relief appears to be a safe choice for those seeking to reduce pain and improve movement, especially when surgery is not an immediate option.12345

Why are researchers excited about this trial?

Most treatments for osteoarthritis, like NSAIDs and corticosteroids, focus on relieving pain and reducing inflammation. But the Empowered Relief program offers something different. It's a single-session, skills-based pain management class designed to provide rapid pain relief through cognitive and behavioral techniques. Researchers are excited about this approach because it empowers patients to manage their pain without the need for medication, potentially reducing side effects and offering a long-term, sustainable solution.

What evidence suggests that the Empowered Relief intervention is effective for osteoarthritis?

Research has shown that Empowered Relief (ER), which participants in this trial may receive, effectively manages osteoarthritis pain. One study found that this one-time, online class significantly improved pain-related outcomes. It combines key techniques from cognitive behavioral therapy (CBT) and mindfulness into a short, easy-to-understand format. Another report indicated that ER works as well as multi-session CBT programs in reducing pain and enhancing quality of life. These findings suggest that ER can help people manage their pain and improve mobility without long therapy sessions.12367

Are You a Good Fit for This Trial?

This trial is for adults with advanced osteoarthritis who can't have hip or knee replacement surgery right now due to medical, surgical, behavioral, or personal reasons. Participants must be at least 18 years old and willing to join the study.

Inclusion Criteria

I am 18 years old or older and want to join the study.

Exclusion Criteria

Any records flagged 'break the glass' or 'research opt out'

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention Delivery

Participants complete the live Empowered Relief online class, a 2-hour intervention equipping them with evidence-based behavioral pain management skills

Single session (2 hours)
1 visit (virtual)

Follow-up

Participants are monitored for safety and effectiveness after treatment

8 weeks
Assessments at baseline, 4 weeks, and 8 weeks post-treatment

What Are the Treatments Tested in This Trial?

Interventions

  • Empowered Relief

Trial Overview

The study compares a single-session online pain management class called Empowered Relief against standard group pain-CBT and a self-management handout. Participants are randomly assigned to one of these three groups.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Test TreatmentExperimental Treatment1 Intervention
Group II: Educational MaterialsActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Cedars-Sinai Medical Center

Lead Sponsor

Trials
523
Recruited
165,000+

Citations

Empowered Relief for Osteoarthritis (OA) Version Date

Our goals are to provide scientific evidence to demonstrate the efficacy of ER, and also provide a comparison of said efficacy against the ...

Empowered Relief for Osteoarthritis · Info for Participants

... Empowered Relief will have tolerable side effects & efficacy for patients with Arthritis and Osteoarthritis. Learn more about the study.

Empowered Relief, cognitive behavioral therapy, and health ...

Accordingly, the current report describes 6-month outcome data for our three-arm randomized comparative efficacy trial. First, we examined ...

Comparing the Effectiveness of Two Online Programs for ...

The project compares the effectiveness of two different online programs for treating chronic pain. Who will this research inform?

Perspective: Empowering osteoarthritis drug development ...

By doing so, it aims to accelerate development of effective disease modifying OA drugs (DMOADs) and improving patient outcomes. It ...

April 9th, 2026 Caryn Lindsey, PhD Cedars-Sinai

The primary objective of this study is to evaluate the efficacy of. Empowered Relief (a novel, single-session (2-hour), evidence-based online ...

Empowered Relief, cognitive behavioral therapy, and ...

Empowered Relief remained non-inferior to CBT on most outcomes, whereas both ER and CBT remained superior to HE on most outcomes.