Arterial Embolization for Osteoarthritis

This trial tests a new treatment called Embozene™ Microspheres, a type of arterial embolization, to determine if it can safely alleviate symptoms in people with knee osteoarthritis (OA). The goal is to see if this procedure can reduce knee pain by blocking certain blood vessels that supply the painful area. In this single-group study, all participants will receive the treatment and be monitored for a year. Individuals with knee OA experiencing moderate to severe pain, despite trying other treatments like painkillers or physical therapy, might be suitable candidates. As an unphased trial, this study provides a unique opportunity to explore a novel treatment option for knee OA.

The trial protocol does not specify whether you need to stop taking your current medications. However, it mentions that knee pain should be resistant to conservative treatments like anti-inflammatory drugs, which suggests you might continue some medications. Please consult with the trial coordinators for specific guidance.

Research has shown that genicular artery embolization (GAE) using Embozene™ Microspheres is generally safe for treating knee osteoarthritis (OA). Studies have found that patients with mild to moderate knee OA tolerate these microspheres well. One study indicated that GAE with these permanent microspheres is safe and may be effective in the early stages. Another study examined the safety of GAE over two years and confirmed its safety for a different group of patients. Overall, this research suggests that GAE is a promising option for reducing knee pain in individuals who haven't found relief with other treatments or aren't suitable for surgery.¹²³⁴⁵

Researchers are excited about Embozene™ Microspheres for osteoarthritis (OA) because they offer a novel way to manage the condition by targeting the blood vessels. Unlike standard treatments such as pain relievers and physical therapy, which focus on symptoms, this approach uses tiny beads to block abnormal blood vessels in the knee. This can reduce inflammation and pain more directly. The potential to improve symptoms with a minimally invasive procedure makes it a promising option for OA patients.

Research has shown that genicular artery embolization (GAE), using Embozene™ Microspheres, can help treat knee osteoarthritis (OA). Studies have found that this treatment leads to lasting improvements in symptoms for individuals with mild to moderate knee OA. Specifically, one study found that participants experienced less pain and improved knee function after the procedure. Another study reported that GAE is safe and offers benefits soon after treatment. Overall, evidence supports that Embozene™ Microspheres effectively reduce knee pain and improve movement in individuals with knee OA. Participants in this trial will receive the Embozene™ Microspheres treatment to further evaluate its effectiveness and safety.¹²³⁴⁶