MRI for Throat Cancer
(OPSCC Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this research study is to investigate the relationship between vascular habitats and treatment response AND to investigate the potential utility of dynamic contrast enhanced (DCE)-MRI derived parameters in predicting treatment response.
This data can be used to assist in the development of a clinical decision support (CDS) tool for risk categorization and individualized decision-making. While "low-risk" patients could benefit from de-escalated radiation therapy, "high-risk" patients could receive early initiation of targeted therapies, or immunotherapies.
Who Is on the Research Team?
Sanjeev Chawla
Principal Investigator
University of Pennsylvania
Are You a Good Fit for This Trial?
This study is for people diagnosed with HPV-positive throat cancer (specifically oropharyngeal squamous cell carcinoma).Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Trial Overview
Researchers are using a special MRI scan called DCE-MRI to see if certain imaging features can predict how well patients respond to treatment. The goal is to help guide future personalized treatment plans.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
You are being asked to complete two research MRI scans with and without contrast because you have been newly diagnosed HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) and plan to receive chemoradiation therapy (CRT). MRI contrast agents act like a dye to make MRI pictures brighter and easier to read. During each MRI scan, you will have an intravenous line (IV line) placed. The IV line allows the contrast agent to be injected into your vein.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Abramson Cancer Center at Penn Medicine
Lead Sponsor
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