Exposure and Response Prevention Therapy for Obsessive-Compulsive Disorder

This trial aims to determine if brain scans can predict and track changes in OCD symptoms in children and teens undergoing Exposure and Response Prevention (ERP) therapy. ERP helps participants confront their OCD fears without performing rituals. Participants will attend 14 weekly therapy sessions, monthly booster sessions, and undergo brain scans to monitor changes. The trial is suitable for those aged 10 to 17 with an OCD diagnosis who understand English and do not have certain medical conditions or devices that conflict with MRI scans. As an unphased trial, this study offers participants a unique opportunity to contribute to groundbreaking research that could enhance OCD treatment strategies for young people.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.

Studies have shown that Exposure and Response Prevention (ERP) therapy is a highly regarded treatment for obsessive-compulsive disorder (OCD). Research indicates that ERP works well for many people, with about 80% experiencing significant relief from their symptoms. However, not everyone improves as much, and around 25% might stop the therapy early.

Exposure and Response Prevention Therapy (ERP) is unique because it specifically targets the fear and avoidance behaviors central to Obsessive-Compulsive Disorder (OCD). While traditional treatments for OCD, such as SSRIs or other forms of cognitive behavioral therapy, focus on managing symptoms or altering thought patterns, ERP directly confronts the anxiety-provoking situations that trigger compulsions. Researchers are excited about ERP because it not only reduces OCD symptoms through repeated, structured exposure but also helps to rewire brain connectivity, potentially leading to lasting changes in how the brain processes anxiety. Plus, the flexibility of delivering ERP in person or via secure telehealth makes it more accessible for participants with varying needs.

Research has shown that Exposure and Response Prevention (ERP) therapy effectively treats obsessive-compulsive disorder (OCD). Studies indicate that about 60% to 85% of patients experience significant improvement after completing ERP treatment. One study reported an average reduction of 38.9% in OCD symptoms, with more than half of the patients seeing their symptoms decrease by over 35%. The benefits of ERP have persisted for at least a year after treatment. ERP is a proven method, widely regarded as one of the best ways to manage OCD. Participants in this trial will receive ERP therapy, which includes 14 weekly sessions followed by booster sessions, to assess its effectiveness in managing OCD symptoms.¹²⁵⁶⁷