Low-intensity Ultrasound for Obsessive-Compulsive Disorder
(LIFU-OCD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to learn whether low-intensity focused ultrasound (LIFU), a non-invasive form of brain stimulation, can change brain activity and improve thinking and decision-making in adults with obsessive-compulsive disorder (OCD). The main questions it aims to answer are:
Can active LIFU change activity in brain pathways involved in OCD? Can active LIFU improve the ability to control thoughts and actions?
Researchers will compare active LIFU with sham LIFU to see whether active LIFU causes changes in brain activity and performance on behavioral tasks.
Participants will:
Complete questionnaires and behavioral tasks. Have magnetic resonance imaging (MRI) scans to measure brain activity and identify the area to receive LIFU.
Receive both active and sham LIFU on separate visits. Have MRI scans and complete behavioral tasks after each LIFU session. Complete assessments of OCD symptoms, safety, and possible side effects.
Who Is on the Research Team?
Kiss HT Kiss, Professor
Principal Investigator
University of Calgary, Cumming School of Medicine, Department of Clinical Neurosciences
Are You a Good Fit for This Trial?
This trial is for adults diagnosed with obsessive-compulsive disorder (OCD). Participants should be able to safely undergo MRI scans and follow study procedures. People with conditions or implants that make MRI unsafe, or other major health issues, may not be eligible.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Low-intensity focused ultrasound (Active)
Trial Overview
The study tests whether low-intensity focused ultrasound (LIFU), a non-invasive brain stimulation technique, can change brain activity and improve thinking in OCD. Each participant receives both real and sham LIFU during different visits for comparison.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Participants will receive sham LIFU during the first stimulation visit, followed by active LIFU during the second stimulation visit one week later.
Participants will receive active LIFU during the first stimulation visit, followed by sham LIFU during the second stimulation visit one week later.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Calgary
Lead Sponsor
Hotchkiss Brain Institute, University of Calgary
Collaborator
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