30 Participants NeededMy employer runs this trial

Pain Reprocessing Therapy for Lower Back Pain

MH
AF
Overseen ByAndrea Furlan, MD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University Health Network, Toronto
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine if Pain Reprocessing Therapy (PRT) can improve symptoms and daily functioning for individuals with chronic low back pain. Researchers will compare PRT to a program focused on education and self-management to identify which method more effectively reduces pain and enhances daily activities. Participants will be randomly assigned to one of the two groups and will attend weekly sessions for eight weeks. Ideal candidates for this trial have experienced persistent back pain for at least three months, occurring on at least half the days in the past six months, and are comfortable speaking and understanding English. As an unphased trial, this study offers participants the chance to contribute to innovative research that could lead to new methods for managing chronic pain.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that Pain Reprocessing Therapy is safe for treating chronic low back pain?

Research has shown that Pain Reprocessing Therapy (PRT) is generally easy for people to handle. In previous studies, about 98% of patients felt better after trying PRT. Additionally, around 66% of participants were either completely free of pain or almost pain-free by the end of the treatment. These results suggest that PRT is not only effective but also safe for most people. No major reports of serious side effects have emerged, indicating that those who have tried PRT usually do not experience significant negative effects.12345

Why are researchers excited about this trial?

Researchers are excited about Pain Reprocessing Therapy (PRT) for lower back pain because it offers a novel approach that focuses on retraining the brain's response to pain. Unlike standard treatments such as medication, physical therapy, or surgery, which primarily address the physical symptoms or structural issues, PRT aims to change the way the brain interprets pain signals, potentially leading to lasting relief. This mind-body approach can be empowering for patients, as it emphasizes self-management and the brain's ability to adapt, which could reduce dependency on medications and invasive procedures.

What evidence suggests that Pain Reprocessing Therapy might be an effective treatment for chronic low back pain?

Studies have shown that Pain Reprocessing Therapy (PRT), which participants in this trial may receive, can greatly reduce chronic low back pain. In some research, 98% of patients reported improvement, with 66% becoming pain-free or almost pain-free. Another study found that PRT significantly reduced pain levels compared to a placebo and regular care. Participants in the PRT group had an average pain score of 1.18, much lower than the control group's score of 2.84. Some patients even reported complete recovery from their back pain after PRT sessions. These findings suggest that PRT might help people manage chronic low back pain more effectively.16789

Who Is on the Research Team?

AD

Andrea D Furlan, MD PhD

Principal Investigator

University Health Network, Toronto

Are You a Good Fit for This Trial?

This trial is for adults aged 18-65 who have had chronic low back pain. Participants should be able to attend weekly sessions and follow study instructions. People with certain medical or psychological conditions may not be eligible.

Inclusion Criteria

I have had back pain for at least 3 months on most days.
My pain level is at least 4 out of 10.
I was assigned male or female at birth.
See 2 more

Exclusion Criteria

Severe active psychiatric disorders such as psychosis or substance use disorder
I currently have cancer in my spine or elsewhere in my body.
I have an untreated inflammatory disorder like ankylosing spondylitis or psoriatic arthritis.
See 5 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either Pain Reprocessing Therapy (PRT) or a Monitoring and Education program over 8 weeks

8 weeks
8 intervention sessions

Follow-up

Participants are monitored for safety and effectiveness after treatment, including assessments at post-intervention and 3-month follow-up

3 months
2 follow-up assessments

What Are the Treatments Tested in This Trial?

Interventions

  • Pain Reprocessing Therapy

Trial Overview

The study compares Pain Reprocessing Therapy (PRT) to a Monitoring and Education Program in people with chronic low back pain. Participants are randomly assigned, complete 8 weekly sessions, wear an activity monitor, and have follow-up assessments.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Treatment Arm - Pain Reprocessing TherapyExperimental Treatment1 Intervention
Group II: Control Arm - Monitoring and EducationActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University Health Network, Toronto

Lead Sponsor

Trials
1,555
Recruited
526,000+

Workplace Safety and Insurance Board

Collaborator

Trials
1
Recruited
60+

Citations

Evidence-based interventions to treat chronic low back pain

A 6-study meta-analysis found a 30% decrease in pain intensity for treatment groups, although the effect on disability was not significant.

Pain Reprocessing Therapy Yields Long-Term Back ...

Some study participants reported full recovery from their back pain after PRT sessions, reduced chronic back pain (CBP) more than placebo ...

3.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/34586357/

Effect of Pain Reprocessing Therapy vs Placebo and Usual ...

Large group differences in pain were observed at posttreatment, with a mean (SD) pain score of 1.18 (1.24) in the PRT group, 2.84 (1.64) in the ...

Pain Reprocessing Therapy Reduces Pain Perception ...

These data indicated that a pain reprocessing therapy intervention may allow individuals with chronic low back pain to cope more effectively ...

Pain Reprocessing Therapy (PRT) | Proven Chronic ...

In the PRT group, 98% of patients improved and 66% of patients were pain-free or nearly pain-free at the end of treatment. These outcomes were largely ...

Pain Reprocessing Therapy Reduces Chronic Back ...

This study found that ~67% of participants were pain-free or nearly pain-free after the treatment, compared to approximately 20% improvement in ...

NCT07696741 | PRT for Chronic Low Back Pain

The results of this study will provide important preliminary data regarding the feasibility and potential clinical benefit of PRT and will ...

Back Pain

Data, Outcomes, and Engagement. This is a randomized clinical trial to evaluate a digital pain reprocessing therapy (PRT) intervention for chronic back pain ( ...

“I don't have chronic back pain anymore”: Patient ...

Fourteen participants (43.8%) acknowledged this process of reduced fear and enhanced feelings of safety as an important step in therapy.