Vagus Nerve Stimulation for Peripheral Neuropathy
What You Need to Know Before You Apply
What is the purpose of this trial?
This purpose of this study is to evaluate whether transcutaneous auricular vagus nerve stimulation (taVNS) improves chemotherapy-induced peripheral neuropathy (CIPN) symptoms by assessing changes in daily symptom trajectories following treatment initiation. The study will also examine potential mechanisms of action through longitudinal assessment of inflammatory biomarkers, corticospinal excitability, and autonomic nervous system function.
Who Is on the Research Team?
Marlon L Wong, PT, PhD
Principal Investigator
University of Miami
Are You a Good Fit for This Trial?
This trial is for people who have nerve pain or numbness caused by chemotherapy. Participants should be adults with symptoms of peripheral neuropathy after cancer treatment.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Sparrow Link (taVNS)
Trial Overview
The study tests a device called Sparrow Link, which delivers gentle electrical stimulation to the ear (taVNS) that participants apply themselves at home. The goal is to see if it helps reduce nerve pain and related symptoms.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Participants in this group will receive a 2-week course of daily self-applied transcutaneous auricular vagus nerve stimulation (taVNS). Participants will use a portable taVNS device at home once daily for 14 consecutive days, applying stimulation to the auricular vagus nerve according to standardized instructions provided by the study team. Each stimulation session will last approximately 60 minutes.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Miami
Lead Sponsor
Gabrielle's Angel Foundation for Cancer Research
Collaborator
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