Proton Beam Radiation Therapy for Brain Tumor
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to test whether proton beam radiation can effectively treat germ cell tumors in the brain and spinal area. Proton beam therapy, a type of radiation, targets tumors more precisely, potentially reducing damage to surrounding healthy tissue and leading to fewer side effects compared to traditional photon radiation. The trial seeks participants aged 3 to 25 with a confirmed germ cell tumor in the central nervous system who have not undergone certain types of radiation therapy. As an unphased trial, this study offers a unique opportunity to advance treatment options for germ cell tumors.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that proton beam radiation therapy is safe for brain tumor treatment?
Research has shown that proton beam radiation therapy can be safer for healthy brain tissue compared to traditional radiation methods. Studies indicate that this treatment controls tumors just as effectively but with less risk to healthy areas. For example, one study found a low risk of serious harm to the brainstem (the lower part of the brain) in patients who received proton beam therapy, suggesting it is well-tolerated.
Another study highlighted that proton therapy focuses directly on the tumor, resulting in less radiation affecting the surrounding healthy tissues. This can lead to fewer side effects compared to other radiation treatments. While all treatments can have side effects, proton beam therapy has demonstrated promising results in protecting healthy tissue.12345Why are researchers excited about this trial?
Proton beam radiation therapy is unique because it uses positively charged particles, called protons, to precisely target brain tumors. Unlike traditional radiation therapies that use X-rays, protons can be controlled to release their energy directly at the tumor site, minimizing damage to surrounding healthy tissues. Researchers are excited about this treatment because it has the potential to reduce side effects and improve outcomes by focusing the radiation dose more accurately, making it a promising option for treating brain tumors.
What evidence suggests that proton beam radiation is effective for brain tumors?
Research has shown that proton beam therapy, which participants in this trial will receive, effectively treats brain tumors. Studies have found that it controls tumors in the brain and spine while reducing side effects like tiredness. It also protects healthy tissue better than traditional radiation, allowing higher doses to safely target the tumor. This can lead to better survival rates and quality of life for patients. Overall, proton beam therapy shows promise in managing brain tumors with fewer negative effects on the body.678910
Who Is on the Research Team?
Shannon MacDonald, MD
Principal Investigator
Massachusetts General Hospital
Are You a Good Fit for This Trial?
This trial is for young people aged 3 to 25 with a confirmed diagnosis of germ cell tumors in the central nervous system. They should have a life expectancy over 12 months, be able to perform daily activities (ECOG status 0-2), and not necessarily have measurable disease. Participants must agree to use contraception.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Preparation
Scans are done to prepare participants for radiation treatment and plan the best way to deliver radiation to the tumor
Radiation Treatment
Participants receive proton beam radiation therapy once a day, 5 days a week, for 4-8 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Proton Beam radiation
Find a Clinic Near You
Who Is Running the Clinical Trial?
Massachusetts General Hospital
Lead Sponsor
Dana-Farber Cancer Institute
Collaborator
National Institutes of Health (NIH)
Collaborator