Interactive Chatbot for Cancer

(GIFTT Trial)

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Abramson Cancer Center at Penn Medicine
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a digital tool, an interactive chatbot, to assist with genetic counseling via telemedicine. The goal is to enhance how family members of children with cancer learn about significant genetic mutations that might also affect them. It targets parents of children with specific genetic markers linked to cancer who have not yet undergone genetic testing for these markers. Participants must speak and understand English and have no significant communication issues that would prevent them from using the tool. As an unphased trial, this study offers participants the chance to contribute to innovative research that could improve genetic counseling for families.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications.

What prior data suggests that this methodology is safe for improving cascade testing?

Research has shown that chatbots used for genetic counseling are generally safe and well-received by users. One study found that chatbots can effectively assess genetic cancer risks without causing major problems. These digital tools have successfully made genetic services more accessible to patients.

Another study highlighted that chatbots like Invitae Gia® comply with privacy laws, ensuring information remains secure during online chats. Many patients find these chatbots easy to use, enhancing the accessibility of genetic counseling.

Although chatbots in genetic counseling are relatively new, no specific safety issues have been reported. Current evidence suggests they provide a safe way to deliver genetic information and counseling.12345

Why are researchers excited about this trial?

Researchers are excited about using an interactive chatbot for cancer because it offers a new way to deliver genetic counseling through digital tools and telemedicine. Unlike traditional face-to-face counseling sessions, this method is more accessible and convenient, especially for patients who live far from medical centers or have mobility issues. Additionally, the chatbot can provide personalized support and information around the clock, making it a flexible option that fits into patients' lives more easily. This innovative approach could revolutionize how we provide support and information to cancer patients, potentially improving their overall experience and outcomes.

What evidence suggests that this interactive chatbot is effective for improving cascade testing for cancer?

Research has shown that chatbots can simplify access to genetic counseling for cancer risk. Studies have found that these chatbots streamline the process of assessing genetic risk, making information more readily available. Both patients and healthcare professionals often trust chatbots to support genetic testing, enhancing value without replacing human experts. Chatbots also help overcome barriers to accessing genetic services, which benefits families dealing with cancer. This technology effectively engages and informs patients about their inherited cancer risks. Overall, chatbots have the potential to make genetic counseling more accessible and efficient.12356

Are You a Good Fit for This Trial?

This trial is for biological parents, age 18 or older, who speak English and have a child with cancer enrolled in the ORIGen study who has a confirmed genetic mutation linked to higher cancer risk.

Inclusion Criteria

I am the biological parent of a child in the ORIGen study with a confirmed genetic variant.
I am 18 years old or older.
* Speak and understand English.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Participants receive genetic counseling via digital tools and telemedicine

6 months
Telemedicine sessions as needed

Follow-up

Participants are monitored for understanding of genetic information and psychosocial impact

6 months
Assessments at baseline, within 7 days post-education, and at 6 months

What Are the Treatments Tested in This Trial?

Interventions

  • Interactive Chatbot

Trial Overview

The study is testing an interactive chatbot combined with telemedicine to help families learn about and pursue genetic testing when their child has a gene that increases cancer risk.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Single ArmExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Abramson Cancer Center at Penn Medicine

Lead Sponsor

Trials
425
Recruited
464,000+

Emory University

Collaborator

Trials
1,735
Recruited
2,605,000+

Baylor College of Medicine

Collaborator

Trials
1,044
Recruited
6,031,000+

Fox Chase Cancer Center

Collaborator

Trials
236
Recruited
39,300+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+

Dana-Farber Cancer Institute

Collaborator

Trials
1,128
Recruited
382,000+

Ann & Robert H Lurie Children's Hospital of Chicago

Collaborator

Trials
275
Recruited
5,182,000+

Citations

Chatbot for the Return of Positive Genetic Screening Results ...

This project aimed to design, implement, and evaluate a chatbot integrated with GPT-4, tailored to support the return of positive genomic screening results.

Uptake of Cancer Genetic Services for Chatbot vs Standard-of ...

For the primary outcome of completion of pretest cancer genetic services, the estimated percentage point difference between groups was 2.0 (95% CI, −1.1 to 5.0 ...

Chatbot Artificial Intelligence for Genetic Cancer Risk ...

Chatbots have been used to streamline genetic cancer risk assessment and counseling and hold promise for reducing barriers to genetic services.

Digital tools and chatbots can expand genetic counseling ...

A groundbreaking new study from the Alliance for Clinical Trials in Oncology aims to test whether digital tools and chatbot technology can ...

Patients' and healthcare professionals' experiences ... - PMC

Both patients and HCPs have positive attitudes towards the Rosa chatbot as a trusted supplement to genetic testing; however, they highlight the ...

Invitae Gia® chatbot: Genetic information assistant

A HIPAA-compliant clinical chatbot, Gia facilitates virtual conversations with patients, including intake of family history and automatic delivery of results.