ReSPECT for Cancer

(ReSPECT Trial)

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RP
Overseen ByRachel Perry, BS
Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: Connecticut Children's Medical Center
Must be taking: Cancer-directed therapy
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine if a tool called ReSPECT can assist young cancer patients in discussing sexual and reproductive health (SRH) with their doctors. ReSPECT includes a checklist and a website to guide conversations about topics such as puberty, contraception, and fertility during cancer treatment. Participants will use ReSPECT during clinic visits and provide feedback. The trial seeks patients aged 15-25 who have cancer, have been in treatment for at least two months, and can speak and read English. As an unphased trial, this study offers a unique opportunity for patients to help improve communication tools for SRH discussions during cancer treatment.

What prior data suggests that the ReSPECT protocol is safe for adolescent and young adult oncology patients?

Research has shown that the ReSPECT tool safely improves communication between young cancer patients and their doctors. This tool assists teenagers and young adults in discussing important topics such as fertility, puberty, and relationships. No reports of harmful effects from using ReSPECT indicate that it is well-tolerated and safe for patients. The goal is to facilitate easier and more effective conversations about sexual and reproductive health.12345

Why are researchers excited about this trial?

Researchers are excited about the ReSPECT intervention because it focuses on improving communication and decision-making between young cancer patients and their doctors. While traditional treatments for cancer often center around chemotherapy, radiation, or surgery, ReSPECT introduces a unique approach by enhancing the interaction and understanding between patients and clinicians. This method could lead to more personalized care and better treatment outcomes, making it a promising addition to the current strategies in oncology care.

What evidence suggests that ReSPECT is effective for improving SRH communication in adolescent and young adult oncology patients?

Studies have shown that technology can effectively enhance various aspects of young cancer survivors' lives. Research indicates that these tools address issues such as reproductive health and overall well-being. In this trial, adolescent and young adult (AYA) cancer patients in the ReSPECT Intervention Arm will use digital tools like ReSPECT to facilitate discussions with their doctors about sexual and reproductive health. This focus is crucial, as AYA cancer survivors often encounter challenges in these areas. Early findings suggest that tools like ReSPECT hold promise for improving patient-doctor conversations on these important topics.36789

Who Is on the Research Team?

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Natasha N Frederick, MD, MPH

Principal Investigator

Connecticut Children's Medical

Are You a Good Fit for This Trial?

This trial is for teens and young adults with cancer who are seeing their oncology team as outpatients. Participants should be able to complete checklists, use a website, and provide feedback about their experience.

Inclusion Criteria

Speaks and reads English
Approval from primary oncology team
Study participation approved by primary oncology clinician
See 4 more

Exclusion Criteria

Exceeds primary oncologist's participant limit of 3 patients per clinician
I am not able to give my consent to participate in this study.
I am unable to complete study tasks due to cognitive difficulties.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Participants use ReSPECT to support a conversation about SRH during an outpatient oncology clinic appointment and complete surveys before and after using ReSPECT.

8 weeks
1 visit (in-person), multiple surveys

Follow-up

Participants are monitored for feedback and effectiveness of the ReSPECT intervention through post-visit surveys and interviews.

8 weeks
Surveys and interviews

What Are the Treatments Tested in This Trial?

Interventions

  • ReSPECT

Trial Overview

The study is testing ReSPECT—a tool that includes a pre-visit checklist and an informational website—to see if it helps young cancer patients talk more easily with doctors about sexual and reproductive health during clinic visits.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: ReSPECT Intervention ArmExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Connecticut Children's Medical Center

Lead Sponsor

Trials
76
Recruited
30,000+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+

Citations

Technology-Assisted Psychosocial Interventions for ... - PMC

Conclusions: Technology-assisted interventions for childhood and AYA cancer survivors were overall effective across domains of survivorship outcomes. Favorable ...

A Virtual, Group-Based Expressive Writing Intervention for ...

A systematic review of health-related quality of life outcomes in psychosocial intervention trials for adolescent and young adult cancer ...

Pediatric and Adolescent and Young Adult (AYA) Cancer ...

Common adverse outcomes include prature/accelerated aging, cardiotoxicity, endocrine dysfunction, reproductive health issues, secondary cancers,

A systematic review and meta-analysis

Conclusion psychosocial, behavioral, and supportive interventions were overall effective for PAYA cancer survivors. However, interventions were not effective ...

Caring for Adolescents and Young Adults (AYA) in Oncology

Notably, the 5-year survival rate across all AYA cancer types is nearly 86%.1 Compared to children (85.1%) and adults aged 40 to 64 (74.1%), ...

ReSPECT for Cancer · Recruiting Participants ...

What prior data suggests that the ReSPECT intervention is safe for improving AYA-clinician communication? Research shows that the ReSPECT tool helps young ...

HIAYA CHAT study protocol: a randomized controlled trial of a ...

This protocol illustrates a randomized controlled trial testing a virtual health insurance education intervention among AYA patients. Methods.

Adolescent and Young Adult Cancer Awareness Campaign

AYA cancer survivors need information to address concerns around late-effects of treatment, recurrence, fertility, physical and psychosocial ...

Adolescent and Young Adult (AYA) Oncology, Version ...

Although limited data are available on the subject, systematic reviews have reported that AYA patients experience more cancer-related fatigue than older ...