Vessel Occlusion for Uterine Fibroids

(Myo-Bleed Trial)

This trial aims to determine if using temporary clamps on blood vessels during fibroid removal surgery can reduce blood loss. It compares two groups: one with clamps and one without. Women undergoing minimally invasive surgery for fibroids, whether a single large one or multiple smaller ones, might be suitable candidates. The goal is to assess if this method makes surgery safer and easier by minimizing bleeding. As an unphased trial, participants contribute to advancing surgical techniques that may enhance safety and outcomes for future patients.

The trial information does not specify whether you need to stop taking your current medications.

Research has shown that temporarily clamping the blood vessels in the uterus and ovaries is generally safe. Studies have found that this method reduces blood loss during surgery, indicating safety. For example, one study reported no serious complications when using this technique. Patients in these studies did not experience severe side effects from the temporary clamping.

Researchers are excited about the trial for temporary clamping of uterine and ovarian vessels to treat uterine fibroids because this method offers a novel alternative to current surgical options. Unlike standard treatments like hysterectomy or myomectomy, which permanently alter the uterus, this technique temporarily blocks blood flow to the fibroids, potentially reducing their size without surgery. This approach is less invasive, aiming to preserve the uterus and possibly enhance recovery times and fertility outcomes for patients.

This trial will compare the use of temporary vessel clamps with no clamps during surgery for uterine fibroids. Research has shown that using temporary clamps on blood vessels in the uterus and ovaries during surgery can significantly reduce blood loss. One study found that temporary blocking of the uterine artery cut blood loss in half, reducing it from an average of 150 ml to about 75 ml. Other studies have confirmed that this technique is safe and effectively reduces the need for blood transfusions. These clamps temporarily stop blood flow to the area, making the surgery less bloody. Overall, temporary clamping appears to be a promising way to manage blood loss during the surgical removal of fibroids (myomectomy).⁴⁶⁷⁸⁹