Exercise for Gender Differences in BDNF Levels
(BDNF-SD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
A single bout of exercise can improve cognitive abilities like memory and attention. These functions help us navigate through everyday life. However, we do not fully understand how exercise improves cognitive abilities. We believe that exercise improves the brain by increasing the amount of BDNF in the blood. BDNF is very important for learning and memory. However, we still do not know if BDNF responds differently to exercise between females and males.
The purpose of this work is to characterize potential sex-differences in the circulating BDNF response to acute exercise. We will test the hypothesis that males will have greater serum and plasma BDNF responses compared to females following a maximal exercise test.
Who Is on the Research Team?
Jeremy J Walsh, PhD
Principal Investigator
McMaster University
Are You a Good Fit for This Trial?
This trial is for healthy adults who are able to perform a maximal exercise test. People with health conditions that prevent safe participation in intense exercise or those taking medications affecting brain chemicals may not be eligible.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- VO2peak Test
Trial Overview
The study tests how one session of intense exercise (a VO2peak test) affects levels of BDNF, a protein important for learning and memory, in men versus women. Researchers want to see if there are differences between the sexes.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Responses will be compared between males and females following a single experimental visit. Participants will complete a incremental ramp test to volitional exhaustion on a cycle ergometer, with venous blood draws characterizing BDNF responses at baseline and during the recovery period up to 1-hour post-exercise.
Find a Clinic Near You
Who Is Running the Clinical Trial?
McMaster University
Lead Sponsor
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