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Compensation: Varies

Number of Visits: 7

40 Participants Needed

THRiVE Program for Mental Health in Veterans

Overseen ByShannon M Blakey, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: RTI International

Disqualifiers: Manic episodes, Severe alcohol use, others

No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to develop and test a new program called THRiVE, designed to improve mental health and reduce suicide risk for veterans transitioning from military to civilian life. The program addresses mental health symptoms and everyday functioning. Veterans who have left the military within the past year and have internet access and a device for video calls might be suitable for this study. Participants will engage in group sessions and complete surveys over approximately five months. As an unphased trial, this study allows veterans to contribute to innovative mental health solutions tailored to their unique transition experiences.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. However, if you are receiving or plan to receive BA therapy for any mental health condition, you would not be eligible to participate.

What prior data suggests that the THRiVE program is safe for veterans?

Research has shown that the THRiVE program helps veterans adjust to civilian life by focusing on mental health and reducing the risk of suicide. THRiVE encourages participants to engage in positive and meaningful activities.

As this is an early study, limited safety data is available. However, similar programs are generally safe and have been used successfully in other mental health settings, suggesting participants are unlikely to experience serious side effects.

While direct evidence from past studies on THRiVE itself is lacking, the program is based on proven methods. Prospective participants can feel confident that the program aims to improve mental health in a supportive environment.¹ ² ³ ⁴ ⁵

Why are researchers excited about this trial?

The THRiVE Program is unique because it focuses on enhancing mental health in veterans by promoting resilience through valued personal experiences. Unlike traditional treatments like medication or cognitive behavioral therapy, which often address symptoms directly, THRiVE aims to empower veterans by helping them connect with their values and build resilience. Researchers are excited about this approach because it could lead to more sustainable mental health improvements by fostering a sense of purpose and personal growth, which are crucial for long-term well-being.

What evidence suggests that the THRiVE program is effective for improving mental health in veterans?

Research has shown that the THRiVE program, which participants in this trial will receive, improves mental health in veterans. In a recent study with 201 female veterans, participants reported mental health improvements after joining THRiVE. The program focuses on personal values and strengths to aid participants. Other studies have found that similar programs can significantly improve issues like PTSD and depression in veterans. This suggests that THRiVE might alleviate mental health symptoms and enhance overall wellness.³ ⁶ ⁷ ⁸ ⁹

Who Is on the Research Team?

Shannon M Blakey, PhD

Principal Investigator

RTI International

Are You a Good Fit for This Trial?

This trial is for U.S. military veterans who recently transitioned to civilian life within the last year and are experiencing mental health challenges like suicidal thoughts or adjustment difficulties. Participants must have internet access, a device with video capabilities, and a private space for attending online sessions.

Inclusion Criteria

I am a U.S. military veteran.

I left the military within the last year.

I have internet and a device with a camera and microphone for online sessions.

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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

THRiVE Program

Participants engage in the THRiVE program, a small-group, peer-led, cross-cutting prevention program for newly separated veterans

2 months

6 sessions

Follow-up

Participants are monitored for mental health symptoms, risk factors for suicidal ideation, and psychosocial functioning outcomes

3 months

1 visit (in-person or virtual)

What Are the Treatments Tested in This Trial?

Interventions

Transition Health and Resilience through Valued Experiences (THRiVE) Program

Trial Overview The THRiVE program aims to improve mental health and reduce suicide risk among new veterans by providing peer-led support groups. The study will assess if this program can attract and keep participants while helping them cope better with their emotions, social interactions, and daily functioning.

How Is the Trial Designed?

1Treatment groups

Experimental Treatment

Group I: THRiVEExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

RTI International

Lead Sponsor

Trials

201

Recruited

942,000+

U.S. Army Medical Research Acquisition Activity

Collaborator

Trials

Recruited

10,500+

Citations

1.pmc.ncbi.nlm.nih.govpmc.ncbi.nlm.nih.gov/articles/PMC8278298/

Transforming Health and Resiliency Through Integration of ...A recent evaluation of 201 female veteran participants in THRIVE demonstrated the effectiveness of this program at improving self-reported mental health ...

2.marketplace.va.govmarketplace.va.gov/innovations/thrive-transforming-health-and-resiliency-through-values-based-experiences

THRIVE Program - Diffusion MarketplaceTHRIVE enhances well-being for Veterans and staff through a 14-week program exploring values and strengths, addressing healthcare topics.

3.mhealth.jmir.orgmhealth.jmir.org/2025/1/e65149

Digital Health Interventions for Military Members, Veterans ...The programs largely focused on veteran populations (28/44, 64%). In total, 51% (20/39) of programs relied on cognitive behavioral approaches ...

4.sciencedirect.comsciencedirect.com/science/article/pii/S1550830723002859

Veterans' lived experiences with the VA's Whole Health ...Most veterans perceived a positive WH experience with improvement of three primary dimensions including mental and emotional, physical, and social wellness.

5.journal-veterans-studies.orgjournal-veterans-studies.org/articles/10.21061/jvs.v11i2.683

Evidence Integration Review of Multimodal Interventions ...Results: Forty studies involving over 7,500 veterans were included. Interventions showed significant improvements in PTSD, depression, and reintegration.

6.clinicaltrials.govclinicaltrials.gov/study/NCT06778278

NCT06778278 | Transition Health and Resilience Through ...The objective of this study is to develop and pilot a program designed to improve mental health outcomes and reduce suicide risk during the transition from ...

7.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/41052716/

Bringing veteran mental health promotion and suicide ...This study involves a one-arm trial to pilot test a BA-based program, called Transition Health and Resilience through Valued Experiences (THRiVE), for NSVs.

8.rti.orgrti.org/insights/military-transition-programs-behavioral-activation

Strengthening Military Transitions Through Behavioral ...In this study, new veterans will receive a Behavioral Activation-based program, called Transition Health and Resilience through Valued ...

9.psu.edupsu.edu/news/social-science-research-institute/story/veterans-mental-health-forged-beyond-battlefield

Veterans' mental health forged beyond the battlefield, ...New research shows that veterans' mental health after leaving the military is shaped by more than just combat, with childhood trauma, ...

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