Brain Stimulation for Memory Loss

(NACC-EC Trial)

This trial aims to determine if combining accelerated deep Transcranial Magnetic Stimulation (dTMS) with cognitive training can improve memory and thinking skills in older adults with memory issues. Participants will receive either real dTMS or a sham version (placebo-like) and will engage in online cognitive exercises. The trial targets individuals aged 55-85 who are concerned about their memory and maintain a stable medication routine. Researchers will assess the safety and tolerability of this approach while collecting early data on its effects on memory. As an unphased trial, this study allows participants to contribute to innovative research that could enhance memory care for older adults.

You need to be stable on your medications for at least 2 months before joining the study and should not expect to change them during the study. If you are on unstable doses of certain medications like antidepressants or memory enhancers, you may not be eligible.

Research has shown that accelerated deep Transcranial Magnetic Stimulation (dTMS) is generally safe and well-tolerated. Studies on people with depression found that these faster treatments are as safe as the standard once-a-day sessions, with no major safety issues reported.

Previous research used dTMS for conditions like Parkinson's and Alzheimer's diseases, indicating a good safety record. Accelerated dTMS targets deeper brain areas, potentially improving memory and thinking skills.

Researchers are excited about the treatment for memory loss because it involves an innovative approach called accelerated neuromodulation of the anterior cingulate cortex. Unlike most treatments that rely on medications, this method uses targeted brain stimulation, specifically intermittent theta-burst stimulation (iTBS). This technique is believed to directly enhance neural pathways associated with memory, potentially offering quicker and more precise improvements in cognitive function. Additionally, combining this with online cognitive remediation could further boost memory performance, offering a holistic approach to managing memory loss.

Research has shown that deep Transcranial Magnetic Stimulation (dTMS) can improve memory by targeting specific brain areas. In this trial, participants will receive either accelerated dTMS combined with mental exercises or sham stimulation with mental exercises. In accelerated dTMS, patients experienced better thinking skills when combined with mental exercises. This method uses magnetic fields to gently stimulate the brain, potentially enhancing memory and thinking. Although still under study, early research suggests this technique could help older adults with memory issues.¹²⁶⁷⁸