PRISM for Medication Adherence

(PRISM Trial)

JL
Overseen ByJulie Lauffenburger, PharmD, PhD
Age: 65+
Sex: Any
Trial Phase: Academic
Sponsor: Brigham and Women's Hospital
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The objective of this study is to test a multidisciplinary care team behavioral intervention to enhance medication adherence among older adults with multiple chronic conditions (MCC). The Personalized Routine and Habit Integration to Support Medication Management (PRISM) intervention is a novel, scalable intervention delivered by pharmacists and occupational therapists (OTs) that aims to improve medication adherence by reducing regimen complexity and solidifying medication habits within daily routines. The goal of this randomized control trial is to evaluate the effectiveness and implementation of PRISM compared with enhanced usual care.

Are You a Good Fit for This Trial?

This trial is for older adults who have multiple ongoing health conditions and take several medications. Participants should be having trouble sticking to their medication schedule.

Inclusion Criteria

Poor medication adherence to at least 1 cardiovascular and/or metabolic medication using validated EHR-data algorithms
Appointment in the past 18 months in the Galter-18 primary care practice
At least 2 cardiovascular and/or metabolic chronic conditions documented in the EHR
See 3 more

Exclusion Criteria

Severe mental illness
Dementia
Dependent on others for medication management
See 1 more

What Are the Treatments Tested in This Trial?

Interventions

  • Personalized Routine and Habit Integration to Support Medication Management (PRISM)

Trial Overview

The study compares two approaches: the PRISM program, where pharmacists and occupational therapists help make taking medicine easier by fitting it into daily routines, versus enhanced usual care. Participants are randomly assigned to one group.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: PRISM ArmExperimental Treatment1 Intervention
Group II: Enhanced usual care (EUC) armExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Brigham and Women's Hospital

Lead Sponsor

Trials
1,694
Recruited
14,790,000+

National Institute on Aging (NIA)

Collaborator

Trials
1,841
Recruited
28,150,000+