Transcranial Magnetic Stimulation for Depression and Opioid Addiction
What You Need to Know Before You Apply
What is the purpose of this trial?
This study will compare transcranial magnetic stimulation (TMS) with sham TMS in people with opioid use disorder who are taking buprenorphine and have major depressive disorder with ongoing depressive symptoms. The study will evaluate whether TMS improves depressive symptoms and reduces opioid craving. The study will also assess smoking behaviors, treatment acceptability, and any side effects related to TMS.
Are You a Good Fit for This Trial?
This trial is for adults with both major depression and opioid addiction who are currently taking buprenorphine but still have depressive symptoms. Participants must be able to safely undergo brain stimulation therapy.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Transcranial Magnetic Stimulation (TMS)
Trial Overview
The study compares real transcranial magnetic stimulation (TMS), a non-invasive brain treatment, to a sham (inactive) TMS in people with depression and opioid use disorder. The goal is to see if TMS helps reduce depression and opioid cravings.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Participants will receive active transcranial magnetic stimulation (TMS) using intermittent theta burst stimulation (iTBS).
Participants will receive sham transcranial magnetic stimulation (TMS) using the same treatment procedure without a significant electric field induced around the brain.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Kentucky
Lead Sponsor
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