Robotic Lobectomy for Lung Cancer

(OTC-RATS Trial)

Not currently recruiting at 1 trial location
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Overseen ByAdeline Jouquan, MSc
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores a new method for performing lung cancer surgery using a robotic system. It focuses on testing the safety and feasibility of this approach for patients with small, early-stage lung tumors. The trial seeks participants who already have lung cancer surgery planned at CHUM using minimally invasive techniques. Eligible participants should have early-stage lung cancer and be scheduled for a specific type of surgery, either a VATS (Video-Assisted Thoracoscopic Surgery) or RATS (Robotic-Assisted Thoracoscopic Surgery) lobectomy. As an unphased trial, this study allows patients to contribute to innovative surgical techniques that may enhance future treatment options.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial team or your doctor.

What prior data suggests that this robotic lobectomy technique is safe for lung cancer patients?

Research has shown that both robotic-assisted thoracic surgery (RATS) and video-assisted thoracic surgery (VATS) are safe and effective for treating early-stage lung cancer. Studies have found that both methods achieve similar success rates in curing the disease. Specifically, RATS often results in less blood loss, shorter chest tube duration, and fewer complications compared to other methods. This suggests that the robotic approach is generally well-tolerated by patients undergoing lung surgery. Although some risk accompanies any surgery, evidence indicates that RATS is generally safe for patients.12345

Why are researchers excited about this trial?

Researchers are excited about the robotic lobectomy for lung cancer because it offers a new way to perform surgery with potentially fewer incisions. Unlike the standard video-assisted thoracoscopic surgery (VATS), this method uses 1 to 4 subcostal ports, which could mean less trauma to the body and quicker recovery times for patients. Additionally, the precision of robotic assistance may enhance the surgeon's ability to navigate complex procedures, potentially improving outcomes and reducing complications.

What evidence suggests that this robotic lobectomy is effective for lung cancer?

Research has shown that robotic-assisted lobectomies, surgeries to remove part of the lung, can lead to better outcomes for lung cancer patients. Studies have found that these surgeries often cause less pain and allow for quicker recovery compared to traditional methods. Specifically, one study found that patients experienced improved well-being and a higher quality of life six weeks post-surgery. Additionally, robotic lobectomies are associated with fewer complications and better long-term survival rates. In this trial, participants will undergo the "Out of the Cage Robotic Lobectomy," which follows the standard steps of VATS/RATS lobectomy with specific modifications to the incisions. Overall, this technique appears to be a promising option for treating early-stage lung cancer.13678

Who Is on the Research Team?

ML

Moishe Liberman, MD

Principal Investigator

Centre hospitalier de l'Université de Montréal (CHUM)

Are You a Good Fit for This Trial?

This trial is for adults with early-stage lung cancer (stage I) who are already scheduled to have a lobectomy, which is surgery to remove a part of the lung, using minimally invasive techniques at CHUM. Pregnant individuals or those unable to consent are not eligible.

Inclusion Criteria

My lung cancer is in an early stage and I am scheduled for a specific type of lung surgery at CHUM.

Exclusion Criteria

I am unable to give consent for the study myself.
Pregnancy
I am under 18 years old.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks
1 visit (in-person)

Treatment

Participants undergo lobectomy by OTC RATS following standard VATS/RATS steps with subcostal ports

Intraoperative
1 visit (in-person)

Postoperative Care

Standard postoperative care including chest tube management and discharge planning

Up to 30 days
Multiple visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness, including 30-day follow-up and 1-year chronic pain assessment

1 year
Follow-up appointments at surgical clinic

What Are the Treatments Tested in This Trial?

Interventions

  • VATS/RATS lobectomy

Trial Overview

The study is testing the feasibility and safety of performing robotic-assisted thoracic surgery (RATS) lobectomies outside the traditional setting ('Outside the Cage') in patients with stage I lung cancer.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Out of the Cage Robotic LobectomyExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Centre hospitalier de l'Université de Montréal (CHUM)

Lead Sponsor

Trials
389
Recruited
143,000+

Citations

Outside the Cage Subcostal RATS Lobectomy - PMC

Abstract. Objective: The goal of minimally invasive surgery is to reduce trauma to patients and improve their postoperative outcomes.

Outside the Cage (OTC) Robotic Lobectomy (OTC-RATS)

This study consists in a prospective pilot study evaluating the feasibility and safety of OTC RATS lobectomies in patients treated for lung cancer.

Outcomes and quality of life after Robot-assisted lobectomy ...

This paper aimed to compare the safety, short-term efficacy, quality of life (QoL), and delayed complications at 6 weeks postoperatively

EP.07 EARLY-STAGE NON-SMALL CELL LUNG CANCER ...

A VATS lobectomy was performed using the 4-port technique. Perioperative and clinicopathologic outcomes were evaluated. Results. The baseline characteristics ...

Examining long-term outcomes after robotic versus video ...

These studies are small in size and generally show a trend towards improved outcomes for RATS, although this benefit is less marked compared to retrospective ...

An update on robot-assisted and video-assisted lobectomies ...

Recent studies indicate that RATS lobectomy is associated with reduced blood loss, shorter chest tube duration, and lower overall complication rates compared ...

Long-Term Oncologic Outcomes in Robot-Assisted and ...

In conclusion, in our series, RATS lobectomy for lung cancer led to a significantly higher DFS and significantly lower recurrence rate compared ...

Long-term outcomes of robotic versus video-assisted ... - PMC

Both robotic- and video-assisted pulmonary lobectomies offer equivalent overall and disease-free survival outcomes in patients with non-small cell lung cancer.