Navy Bean-Rich Diet for Fatty Liver Disease
(BEAN-MASLD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether a diet rich in navy beans can benefit individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) and moderate liver scarring (fibrosis). Participants will follow two diets: their regular diet and one where navy beans replace some usual foods, guided by dietitians. The trial aims to determine if participants can adhere to this diet and find it acceptable. This study may suit adults with doctor-confirmed MASLD and liver fibrosis, who maintain stable medication use, and are willing to eat navy beans regularly. As an unphased trial, it offers an opportunity to explore a potentially beneficial dietary approach for liver health.
What prior data suggests that the navy bean-rich diet is safe for adults with MASLD?
Research has shown that a diet rich in navy beans might be a safe choice for people with fatty liver disease. Studies have found that increasing bean consumption can reduce liver fat and improve liver health. Beans are part of the Mediterranean diet, which is known to help with liver issues even without weight loss.
Regarding safety, no specific reports of serious side effects from eating navy beans exist. Most people tolerate beans well, though some might experience mild digestive issues like gas. However, these are common and usually not harmful. This makes a navy bean-rich diet a promising and safe option for those looking to improve liver health through dietary changes.12345Why are researchers excited about this trial?
Unlike the standard treatments for fatty liver disease, which often involve medications or lifestyle changes like exercise and weight loss, a navy bean-rich diet offers a natural and food-based approach. Researchers are excited about this treatment because navy beans are high in fiber and antioxidants, which can help improve liver health by reducing inflammation and fat accumulation. This dietary approach is also easily accessible, potentially making it a sustainable and cost-effective option for managing the disease.
What evidence suggests that a navy bean-rich diet could be effective for fatty liver disease?
Research has shown that eating more legumes, such as navy beans, can help with fatty liver disease. One study found a link between increased legume consumption and a lower risk of this condition. Another study discovered that beans can reduce liver fat, which is important because less fat in the liver can lead to less liver damage. Additionally, diets including beans may improve liver health by lowering liver-related enzymes and fat content. This trial will evaluate the effects of a navy bean-rich diet on liver health. Participants will follow a navy bean-rich diet in one phase and their habitual diet in another phase. These findings suggest that a diet rich in navy beans could benefit people with liver issues related to metabolic problems.12367
Who Is on the Research Team?
Xiaotao Zhang, MD, PhD
Principal Investigator
Icahn School of Medicine at Mount Sinai
Are You a Good Fit for This Trial?
This trial is for adults diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD) who have moderate liver scarring (stage F2-F3).Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment Phase 1
Participants follow either a habitual diet or a navy-bean-rich diet for 12 weeks
Treatment Phase 2
Participants cross over to the alternate diet for another 12 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Navy Bean-Rich Diet
Trial Overview
The study compares a regular diet to one where navy beans are swapped in for other foods, keeping calories the same. Each participant tries both diets for 12 weeks each, guided by dietitians.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Participants follow the isocaloric navy-bean-rich diet during Period 1 (12 weeks), then cross over to their habitual diet during Period 2 (12 weeks).
Participants follow their habitual diet during Period 1 (12 weeks), then cross over to the isocaloric navy-bean-rich diet during Period 2 (12 weeks).
Find a Clinic Near You
Who Is Running the Clinical Trial?
Icahn School of Medicine at Mount Sinai
Lead Sponsor
Citations
Thwarting Metabolic Dysfunction-Associated Fatty Liver ... - PMC
Consumption of bean markedly reduced the lipid content per g liver dry weight in both females and males (Figure 1).
Dietary Patterns, Foods, and Nutrients to Ameliorate Non- ...
Conclusions: A high-quality diet could improve liver steatosis. Weight loss through hypocaloric diet together with physical activity and limited sugar intake ...
3.
mayoclinic.org
mayoclinic.org/diseases-conditions/fatty-liver-disease-masld/in-depth/fatty-liver-disease-masld-diet/art-20588469Fatty liver disease (MASLD) diet
Eating a Mediterranean diet can help you lose weight. Losing 5% to 10% of body weight can significantly improve MASLD.
Fatty Liver Diet: What Foods to Eat and Avoid
LD Both beans and soy have shown promise in reducing the risk of NAFLD. a 2019 study found diets rich in legumes specifically helped lower the likelihood of ...
Legume intake and risk of nonalcoholic fatty liver disease
Our findings suggest that higher intake of total legumes (beans, lentils, and peas) was associated with lower risk of NAFLD.
Are Green Beans Good for Fatty Liver? Evidence and ...
Summary: Green beans are beneficial for fatty liver disease as part of a liver-protective dietary pattern, providing fibre, antioxidants, and ...
7.
trial.medpath.com
trial.medpath.com/clinical-trial/3efea10fb46b95cd/nct07730853-navy-bean-substitution-masld-trialIsocaloric Navy-Bean Substitution in... | Clinical Trial
This study is a 24-week randomized crossover feasibility trial evaluating an isocaloric navy-bean dietary substitution in 40 adults with ...
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