50 Participants NeededMy employer runs this trial

Time-Restricted Eating for Cancer

JF
Overseen ByJane Figueiredo, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Fred Hutchinson Cancer Center
Stay on Your Current MedsYou can continue your current medications while participating
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether eating within a specific daily time frame can improve cancer treatment outcomes and overall health. It targets individuals with solid tumors who have undergone surgery and are beginning additional treatments such as chemotherapy or radiation. Participants will either adopt time-restricted eating (consuming all meals within an 8-hour window) or maintain their usual eating habits. The trial seeks individuals who have had surgery for solid tumors and are about to start further treatment. As an unphased trial, it provides a unique opportunity to contribute to research that could enhance future cancer care strategies.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that time-restricted eating is safe for cancer patients?

Research has shown that time-restricted eating (TRE) might be a safe option for people undergoing cancer treatment. In one study, patients who followed TRE adhered to the eating schedule well (67–98% of the time) and reported feeling better during their treatment.

Another study found that TRE can enhance the effectiveness of chemotherapy and reduce its side effects, potentially helping patients manage their cancer treatments more easily. TRE has also improved metabolic health, which is linked to better overall outcomes during cancer care.

Overall, TRE appears to be well-tolerated and might offer benefits without causing significant harm. However, discussing any new treatment approach with a healthcare provider is always important to ensure it is appropriate.12345

Why are researchers excited about this trial?

Researchers are excited about time-restricted eating (TRE) for cancer because it offers a unique approach by altering the timing of food intake rather than focusing on specific drugs or chemotherapy. Unlike traditional cancer treatments that often involve medication or invasive procedures, TRE uses a natural cycle of eating and fasting, which could potentially improve metabolic health and enhance the body's natural defenses against cancer. This method is intriguing because it might reduce side effects and improve quality of life for patients, offering a new complementary strategy alongside existing treatments.

What evidence suggests that time-restricted eating could be an effective treatment for cancer?

This trial will compare time-restricted eating (TRE) with a control group to evaluate its effects on cancer treatment. Research has shown that TRE might enhance the effectiveness of cancer treatments. Animal studies have found that fasting can improve chemotherapy success and reduce its side effects. TRE, a type of fasting where eating is limited to certain hours of the day, is easier to follow than fasting for an entire day. It may protect healthy cells and weaken cancer cells. Some research also suggests that TRE can improve insulin management and reduce other health issues, which could be beneficial during cancer treatments. Additionally, TRE has proven easy for participants to maintain and can enhance their quality of life.12367

Who Is on the Research Team?

JF

Jane Figueiredo, PhD

Principal Investigator

Cedars-Sinai Medical Center

TT

Timothy Thomas, MD

Principal Investigator

Alaska Native Tribal Health Consortium (ANTHC)

Are You a Good Fit for This Trial?

This trial is for adults (18+) of any gender who have had surgery to remove a solid tumor and are about to start chemotherapy, targeted therapy, immunotherapy, or radiation. Participants must have a BMI of at least 18.5 and be able to follow study procedures. Pregnant/breastfeeding people and those already fasting most days can't join.

Inclusion Criteria

Willing and able to adhere to the assessments, visit schedules, prohibitions, and restrictions
I am 18 years old or older.
My sex or gender does not affect my eligibility.
See 2 more

Exclusion Criteria

Pregnant or breastfeeding
Strictly adhering to a <10-hour eating window on most days
I do not plan to have additional drug therapy after surgery.
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo adjuvant therapy with either time-restricted eating or a control eating schedule

6 months
Weekly one-on-one nutrition counseling during the first month, then monthly

Follow-up

Participants are monitored for safety and effectiveness after treatment

6-12 months

What Are the Treatments Tested in This Trial?

Interventions

  • Time-restricted eating

Trial Overview

The study tests if eating only during certain hours each day (time-restricted eating) helps cancer patients during treatment. It also includes health coaching, questionnaires, and sample collection. The goal is to see if this meal timing improves treatment results and overall health.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Time-restricted eating (TRE)Experimental Treatment4 Interventions
Group II: Control groupActive Control3 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Fred Hutchinson Cancer Center

Lead Sponsor

Trials
583
Recruited
1,341,000+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+

Alaska Native Tribal Health Consortium

Collaborator

Trials
20
Recruited
9,600+

Alaska Native Medical Center

Collaborator

Trials
4
Recruited
810+

Cedars-Sinai Medical Center

Collaborator

Trials
523
Recruited
165,000+

Citations

The Clinical Impact of Time-restricted Eating on Cancer - PMC

A high rate (67–98%) of TRE adherence was observed, alongside improvements in quality of life. Four articles assessed cancer markers and found a ...

Time-restricted eating and cancer: lessons learned and ...

Full achievement of the potential of time-restricted eating would lead to decreased metabolic dysfunction, with a reduction in cancer risk and increased ...

Time Restricted Eating During Chemotherapy for Breast ...

Pre-clinical murine studies report intermittent fasting increases effectiveness of chemotherapy and decreases treatment related adverse events.

Time-restricted eating and cancer care

This study is testing TRE to reduce cancer progression and cognitive side effects following radiation treatment of brain metastases from breast ...

5.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/39212676/

The Clinical Impact of Time-restricted Eating on Cancer

A high rate (67-98%) of TRE adherence was observed, alongside improvements in quality of life. Four articles assessed cancer markers and found a ...

Obesity, cancer risk, and time-restricted eating - PMC - NIH

Given that TRE improves metabolic health in obese animals and humans, it might be expected to have anti-cancer effects in obesity-driven cancers. This has been ...

NCT05038137 | Time Restricted Eating on Cancer Risk

Percentage of dietary visits that participant reported compliance with randomized eating period. Visit 1 (0 weeks), Visit 2 (14 weeks). Secondary Outcome ...