Pistachios for Obesity
What You Need to Know Before You Apply
What is the purpose of this trial?
This randomized controlled crossover study will examine the acute effects of pistachio consumption on postprandial metabolic responses in adults with overweight or obesity. Participants will complete two experimental conditions in randomized order. In one condition, participants will consume 30 g of pistachios with a standardized meal, and in the other condition they will receive an isocaloric refined-carbohydrate control condition with the standardized meal.
The study will evaluate postprandial insulin and glucose responses over approximately 3 hours after meal consumption. Additional outcomes will include continuous glucose monitoring measures, blood lipid responses, appetite and satiety ratings, and exploratory measures related to insulin sensitivity and gastrointestinal hormone responses. The study is designed to determine whether pistachio consumption alters acute metabolic responses compared with an isocaloric refined-carbohydrate control in adults with overweight or obesity.
Who Is on the Research Team?
Hossein Rafiei, PhD, RD
Principal Investigator
St. Louis University
Are You a Good Fit for This Trial?
This trial is for adults who are overweight or have obesity. Participants should not have any major health conditions that would interfere with the study, but specific inclusion and exclusion details are not provided.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Trial Overview
The study compares how eating pistachios versus a refined carbohydrate with a meal affects blood sugar, insulin, cholesterol, appetite, and related measures in people with overweight or obesity. Each participant tries both options in random order.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Participants randomized to this sequence will first complete the pistachio condition, in which 30 g of shelled pistachios are consumed with the standardized high-glycemic breakfast meal. After a 3-7 day washout period, participants will complete the refined-carbohydrate control condition, in which an isocaloric refined-carbohydrate control food is consumed with the same standardized breakfast meal.
Participants randomized to this sequence will first complete the refined-carbohydrate control condition, in which an isocaloric refined-carbohydrate control food is consumed with the standardized high-glycemic breakfast meal. After a 3-7 day washout period, participants will complete the pistachio condition, in which 30 g of shelled pistachios are consumed with the same standardized breakfast meal.
Find a Clinic Near You
Who Is Running the Clinical Trial?
St. Louis University
Lead Sponsor
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