Influenza Transmission Study
(FLU-TIDE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to determine whether influenza A or B can be transmitted from adults with naturally acquired community influenza infection to healthy adult recipients under controlled inpatient exposure conditions, and to identify donor, recipient, viral, immunologic, behavioral, and environmental factors associated with transmission.
This study differs from a traditional influenza CHIM because no challenge stock will be administered. Instead, naturally infected community donors will serve as the source of exposure. This approach is intended to better reflect naturally circulating influenza viruses and naturally infected donors while preserving the safety advantages of inpatient monitoring, defined exposure windows, controlled environmental measurements, and standardized sampling.
Who Is on the Research Team?
Nadine Rouphael, MD, MSc
Principal Investigator
Emory University
Are You a Good Fit for This Trial?
This trial is for healthy adults who have not recently had the flu. Some will be people with a natural, recent influenza infection (donors), and others will be healthy volunteers exposed to them (recipients). People with certain health conditions or risks may not be able to join.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Trial Overview
Researchers are studying how flu spreads by having healthy adults stay in a controlled setting and interact with people who naturally caught the flu. No one is deliberately infected; instead, exposure happens through contact under close medical supervision.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Healthy adult recipients are admitted to the Emory University Hospital challenge unit and intentionally exposed to one or more naturally infected donors under controlled inpatient conditions over multiple exposure days.
Adults with naturally acquired community influenza A or B infection are enrolled as donors.These donors are not experimentally infected by the study. Instead, donors are identified rapidly from the community, tested by rapid antigen and/or polymerase chain reaction (PCR), and brought to the controlled exposure unit for same-day donor visits.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Emory University
Lead Sponsor
National Philanthropic Trust (NPT)
Collaborator
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