Morning Light Therapy for Inflammatory Bowel Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether morning light therapy can help adults with ulcerative colitis, a type of inflammatory bowel disease, who also have trouble sleeping. The aim is to determine if this therapy can improve sleep quality and reduce inflammation. Participants will use morning light therapy for an hour each day while tracking their sleep and symptoms. The trial seeks individuals with ulcerative colitis experiencing active inflammation and poor sleep. As an unphased trial, it offers a unique opportunity to explore a novel approach to managing symptoms and improving quality of life.
Will I have to stop taking my current medications?
You may need to stop taking certain medications, especially those affecting sleep or the autonomic nervous system, like beta-blockers, benzodiazepines, and sleep medications. If you regularly use these, you might need a 4-week period without them before joining the study.
What prior data suggests that morning light therapy is safe for patients with ulcerative colitis?
Research has shown that morning light therapy (MLT) is generally safe and well-tolerated for people with inflammatory bowel disease (IBD), including ulcerative colitis (UC). Studies have found MLT to be a practical and acceptable treatment option. No major reports of serious side effects have emerged from this therapy. Most patients manage the therapy without significant problems, suggesting it could be a good choice for those seeking alternative ways to manage their symptoms.12345
Why are researchers excited about this trial?
Unlike the standard treatments for ulcerative colitis, which often include medications like aminosalicylates, corticosteroids, or immunosuppressants, morning light therapy offers a novel, non-drug approach. Researchers are excited about this treatment because it harnesses natural light exposure to potentially regulate the body's circadian rhythms and reduce inflammation. This could provide a gentler alternative with fewer side effects, offering hope for those who struggle with the side effects of traditional medications.
What evidence suggests that morning light therapy might be an effective treatment for ulcerative colitis?
Research suggests that morning light therapy, which participants in this trial will receive, can help individuals with inflammatory bowel disease (IBD), such as ulcerative colitis, by improving symptoms and reducing disease activity. Morning light resets the body's internal clock, potentially enhancing sleep and reducing inflammation. Studies have shown that this therapy eases symptoms by aligning sleep patterns with natural light cycles. As a result, patients might experience less inflammation and better overall health. Although more research is needed, early findings are encouraging.12356
Who Is on the Research Team?
Hyder Said
Principal Investigator
Icahn School of Medicine at Mount Sinai
Robert Hirten, MD
Principal Investigator
Icahn School of Medicine at Mount Sinai
Are You a Good Fit for This Trial?
Adults with ulcerative colitis, poor sleep quality, and active inflammation can join this trial. They must not be pregnant or lactating, have a pacemaker/defibrillator, work night shifts, use drugs/marijuana recently, have serious health issues like heart attack/stroke/failure of kidneys or liver/infections, take certain medications affecting the nervous system/sleep/IBD treatment changes in last 3 months. Those with recent surgery or untreated sleep apnea are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Lead-in
Participants obtain baseline circadian-related labs, complete symptom-related surveys, and use a wearable device continuously to obtain baseline sleep-wake data
Treatment
Participants undergo one hour of morning light therapy while wearing wearable devices continuously and completing daily symptom surveys
Follow-up
Participants obtain post-intervention circadian and inflammatory assessments and complete the same symptom-related surveys
What Are the Treatments Tested in This Trial?
Interventions
- Morning Light Therapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
Icahn School of Medicine at Mount Sinai
Lead Sponsor