Sucralose for Inflammatory Bowel Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This study will focus on the commonly used non-nutritive sweetener (NNS) sucralose (2 sachets/day resulting in daily dose: sucralose 2.5mg/kg) and its role in changing the gut microbiota in humans with IBD, compared to healthy non-IBD individuals. The investigators will focus on studying IBD patients affected with CD as a proof of principle that could be tested later in other IBD subtype (ulcerative colitis or others specific surgical conditions).
Who Is on the Research Team?
Fabio Cominelli, MD PhD
Principal Investigator
University Hospitals Cleveland Medical Center
Abigail Raffner, RD PhD
Principal Investigator
Case Western Reserve University
Are You a Good Fit for This Trial?
This trial is for adults diagnosed with Crohn's disease (a type of inflammatory bowel disease) and healthy people without IBD. Participants should not have other types of IBD or recent surgeries related to the gut.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline
Removal of all non-nutritive sweeteners from the diet
Sucralose Intervention
Participants consume sucralose (2 sachets/day) to study its effect on gut microbiota
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Sucralose
Trial Overview
The study tests how taking sucralose, a common artificial sweetener, affects gut bacteria in people with Crohn's disease compared to healthy individuals. Participants will consume two sachets of sucralose daily.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Healthy control participants will consume artificial sweetener: sucralose
Crohn's participants will consume artificial sweetener: sucralose
Find a Clinic Near You
Who Is Running the Clinical Trial?
University Hospitals Cleveland Medical Center
Lead Sponsor
Crohn's and Colitis Foundation
Collaborator
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